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Derives from the Greek word "Dromos," meaning avenue or entranceway to a building. A dromotropic agent is one which affects the conduction velocity of the AV node, and subsequently the rate of electrical impulses in the heart.[1][2]
Agents that are dromotropic are often (but not always) inotropic and chronotropic. For example, parasympathetic stimulation is usually negatively dromotropic, inotropic, and chronotropic.
Non-dihydropyridine calcium channel blockers such as verapamil block the slow inward calcium current in cardiac tissues thereby having a negatively dromotropic, chronotropic and inotropic effect[3]. This (and other) pharmacological effect makes these drugs useful in the treatment of angina pectoris. Conversely, they can lead to symptomatic disturbances in cardiac conduction and bradyarrhythmias, and may aggravate left ventricular failure[4].
Relating to or influencing the conductivity of nerve fibers or cardiac muscle fibers
References
- ^ Chronotropic and dromotropic responses to stimulation of intracardiac sympathetic nerves to sinoatrial or atrioventricular nodal region in anesthetized dogs - Furukawa et al. 66 (5): 1391 - Circulation Research
- ^ Dromotropic at eMedicine Dictionary
- ^ eTG complete
- ^ AccessMedicine - Harrison's Internal Medicine: Stable Angina Pectoris
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