Endothelin receptor type A

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Endothelin receptor type A
Identifiers
Symbols EDNRA; ETA; ETRA
External IDs OMIM: 131243 MGI: 105923 HomoloGene: 1478
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1909 13617
Ensembl ENSG00000151617 ENSMUSG00000031616
Uniprot P25101 Q61614
Refseq NM_001957 (mRNA)
NP_001948 (protein)		 NM_010332 (mRNA)
NP_034462 (protein)
Location Chr 4: 148.62 - 148.69 Mb Chr 8: 80.56 - 80.62 Mb
Pubmed search [1] [2]

Endothelin receptor type A, also known as EDNRA, is a human gene which encodes a G protein-coupled receptor.[1]


See also

References

  1. ^ "Entrez Gene: EDNRA endothelin receptor type A".

Further reading

  • Arai H, Nakao K, Hosoda K, et al. (1993). "[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]". Jpn. Circ. J. 56 Suppl 5: 1303–7. PMID 1291713. 
  • Hosoda K, Nakao K, Tamura N, et al. (1992). "Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor.". J. Biol. Chem. 267 (26): 18797–804. PMID 1326535. 
  • Hayzer DJ, Rose PM, Lynch JS, et al. (1992). "Cloning and expression of a human endothelin receptor: subtype A.". Am. J. Med. Sci. 304 (4): 231–8. PMID 1415318. 
  • Hosoda K, Nakao K, Hiroshi-Arai, et al. (1991). "Cloning and expression of human endothelin-1 receptor cDNA.". FEBS Lett. 287 (1-2): 23–6. PMID 1652463. 
  • Cyr C, Huebner K, Druck T, Kris R (1992). "Cloning and chromosomal localization of a human endothelin ETA receptor.". Biochem. Biophys. Res. Commun. 181 (1): 184–90. PMID 1659806. 
  • Adachi M, Yang YY, Furuichi Y, Miyamoto C (1991). "Cloning and characterization of cDNA encoding human A-type endothelin receptor.". Biochem. Biophys. Res. Commun. 180 (3): 1265–72. PMID 1719979. 
  • Lin HY, Kaji EH, Winkel GK, et al. (1991). "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor.". Proc. Natl. Acad. Sci. U.S.A. 88 (8): 3185–9. PMID 1849646. 
  • Takigawa M, Sakurai T, Kasuya Y, et al. (1995). "Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors.". Eur. J. Biochem. 228 (1): 102–8. PMID 7882989. 
  • Kobayashi S, Tang R, Wang B, et al. (1994). "Binding and functional properties of endothelin receptor subtypes in the human prostate.". Mol. Pharmacol. 45 (2): 306–11. PMID 8114678. 
  • Yang H, Tabuchi H, Furuichi Y, Miyamoto C (1993). "Molecular characterization of the 5'-flanking region of human genomic ETA gene.". Biochem. Biophys. Res. Commun. 190 (2): 332–9. doi:10.1006/bbrc.1993.1052. PMID 8427579. 
  • Elshourbagy NA, Korman DR, Wu HL, et al. (1993). "Molecular characterization and regulation of the human endothelin receptors.". J. Biol. Chem. 268 (6): 3873–9. PMID 8440682. 
  • Miyamoto Y, Yoshimasa T, Arai H, et al. (1996). "Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts.". Biochem. J. 313 ( Pt 3): 795–801. PMID 8611157. 
  • Horstmeyer A, Cramer H, Sauer T, et al. (1996). "Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification.". J. Biol. Chem. 271 (34): 20811–9. PMID 8702836. 
  • Freedman NJ, Ament AS, Oppermann M, et al. (1997). "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.". J. Biol. Chem. 272 (28): 17734–43. PMID 9211925. 
  • Bourgeois C, Robert B, Rebourcet R, et al. (1997). "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.". J. Clin. Endocrinol. Metab. 82 (9): 3116–23. PMID 9284755. 
  • Mao XQ, Gao PS, Roberts MH, et al. (1999). "Variants of endothelin-1 and its receptors in atopic asthma.". Biochem. Biophys. Res. Commun. 262 (1): 259–62. doi:10.1006/bbrc.1999.1158. PMID 10448102. 
  • Maggi M, Barni T, Fantoni G, et al. (2000). "Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons.". J. Clin. Endocrinol. Metab. 85 (4): 1658–65. PMID 10770212. 
  • Shraga-Levine Z, Sokolovsky M (2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific.". Cell. Mol. Neurobiol. 20 (3): 305–17. PMID 10789830. 
  • Lee HJ, Chun M, Kandror KV (2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling.". J. Biol. Chem. 276 (20): 16597–600. doi:10.1074/jbc.C000909200. PMID 11262386. 
  • Paasche JD, Attramadal T, Sandberg C, et al. (2001). "Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways.". J. Biol. Chem. 276 (36): 34041–50. doi:10.1074/jbc.M103243200. PMID 11382773. 

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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP, EP (1, 2, 3, 4), PGF) • Prostacyclin • Thromboxane
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5)
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182)
Adenosine (A1, A2a, A2b, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) • Adrenomedullin • Anaphylatoxin (C3a, C5a) • Angiotensin (1, 2) • Apelin • Bile acid • Bombesin (BRS3, GRPR, NMBR) • Bradykinin (B1, B2) • Cannabinoid (CB1, CB2) • Chemokine • Cholecystokinin (A, B) • Dopamine (D1, D2, D3, D4, D5) • EBI2 • Endothelin (A, B) • Estrogen • Formyl peptide (1, L1, L2) • Free fatty acid (1, 2, 3, 4) • FSH • Galanin (1, 2, 3) • Gonadotropin-releasing hormone (1, 2) • Ghrelin • Histamine (H1, H2, H3, H4) • Kisspeptin • Luteinizing hormone/choriogonadotropin • Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanocortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Melatonin (1A, 1B) • Motilin • Neuromedin (B, U (1, 2)) • Neurotensin (1, 2) • Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) • Olfactory • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Orexin (1, 2) • Oxytocin • Oxoglutarate • PAF • Prokineticin (1, 2) • Prolactin-releasing peptide • Protease-activated (1, 2, 3, 4) • Relaxin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • SREB • Succinate • TAAR (1, 2, 3, 5, 6, 8, 9) • Tachykinin (1, 2, 3) • Thyrotropin • Thyrotropin-releasing hormone • Urotensin-II • Vasopressin (1A, 1B, 2)
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50)
Other
Calcium-sensing receptor • GABA B (1, 2) • Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4)
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) • Smoothened

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  • This page was last modified on 8 July 2008, at 11:45.

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