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Epithelioid histiocytes (Epithelioid cells) are activated macrophages resembling epithelial cells:[1] elongated, with finely granular, pale eosinophilic (pink) cytoplasm and central, ovoid nucleus(oval or elongate), which is less dense than that of a lymphocyte. They have indistinct shape contour, often appear to merge into one another and form aggregates.
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Clinical significance
The presence of epithelioid histiocytes may characterise some pathologic conditions, mainly granulomatous inflammation, including Orofacial granulomatosis[2]. The excessive proliferation of them on skin causes reticulohistiocytoma and somewhat it is associated with arthritis.
See also
References
- ^ "Dorlands Medical Dictionary:epithelioid cell".
- ^ Bogenrieder T, Rogler G, Vogt T, Landthaler M, Stolz W (2003). "Orofacial granulomatosis as the initial presentation of Crohn's disease in an adolescent". Dermatology (Basel) 206 (3): 273–8. doi:. PMID 12673090.
External links
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- This page was last modified on 4 August 2008, at 03:23.
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