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The Epoxyeicosatrienoic acids or EETs are signaling molecules formed by the action of Cytochrome P450 epoxygenase on 20-carbon essential fatty acids, such as arachidonic acid. These nonclassic eicosanoids act as short-range hormones, (i.e. they are autocrine and paracrine mediators) of the cardiovascular system and kidney. They produce vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects.
Biological effects
EETs are cardioprotective after ischemic heart attack and reperfusion. They act in the corpus cavernosum to maintain penile erection. Specific epoxidation of EET sites produces endogenous PPARα agonists.
References
- ^ Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ.. "Epoxyeicosatrienoic acids (EETs) in cardioprotection: Ischemic versus reperfusion injury.". Am J Physiol Heart Circ Physiol. date=2006 Feb 10. Retrieved on 2006-03-11.
- ^ Jin L, Foss CE, Zhao X, Mills TM, Wang MH, McCluskey LP, Yaddanapud GS, Falck JR, Imig JD, Webb RC. (2006 Jan 13.). "Cytochrome P450 epoxygenases provide a novel mechanism for penile erection.". FASEB J. 2006 Mar;20(3):539-41.. Retrieved on 2006-03-11.PubMed cite.
- ^ Spector AA,Fang X, Snyder GD, Weintraub NL (Jan 2004). "Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function". Prog Lipid Res 43 (1): 55–90. doi:. PMID 14636671.
- ^ Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL (Jul 2007). "Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha". Drug Metab Dispos 37 (7): 1126–1134. doi:. PMID 17431031.
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