Ethionamide

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Ethionamide
Systematic (IUPAC) name
2-ethylpyridine-4-carbothioamide
Identifiers
CAS number 536-33-4
ATC code J04AD03
PubChem 2761171
DrugBank APRD00961
Chemical data
Formula C8H10N2S 
Mol. mass 166.244 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding Approximately 30% bound to proteins.
Metabolism  ?
Half life 2 to 3 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Ethionamide (2-ethylthioisonicotinamide, Trecator SC) is an antibiotic used in the treatment of tuberculosis.

It is a prodrug.[1]

It has been proposed for use in combination with gatifloxacin.[2]

The action may be through disruption of mycolic acid.[3]

References

  1. ^ Vannelli TA, Dykman A, Ortiz de Montellano PR (April 2002). "The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase". J. Biol. Chem. 277 (15): 12824–9. doi:10.1074/jbc.M110751200. PMID 11823459. 
  2. ^ Cynamon MH, Sklaney M (August 2003). "Gatifloxacin and ethionamide as the foundation for therapy of tuberculosis". Antimicrob. Agents Chemother. 47 (8): 2442–4. PMID 12878502. PMC:166105. 
  3. ^ Quémard A, Lanéelle G, Lacave C (June 1992). "Mycolic acid synthesis: a target for ethionamide in mycobacteria?". Antimicrob. Agents Chemother. 36 (6): 1316–21. PMID 1416831. PMC:190338. 
v • d • e
Antimycobacterials (J04)
Tuberculosis/
tuberculosis treatment
Ethionamide, Protionamide, Tiocarlide
Others
Leprosy/
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  • This page was last modified on 11 July 2008, at 02:24.

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