Fenoldopam

This MedLibrary.org supplementary page on Fenoldopam is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

Fenoldopam
Systematic (IUPAC) name
8-chloro-2-(4-hydroxyphenyl)- 4-azabicyclo[5.4.0] undeca-7,9,11-triene-9,10-diol
Identifiers
CAS number 67227-57-0
ATC code C01CA19
PubChem 3341
DrugBank APRD00969
Chemical data
Formula C16H16ClNO3 
Mol. mass 305.756 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic (CYP not involved)
Half life 5 minutes
Excretion Renal (90%) and fecal (10%)
Therapeutic considerations
Licence data

US
Pregnancy cat.

B(US)
Legal status
Routes Intravenous

Fenoldopam (marketed as Corlopam) is a synthetic compound that acts as a selective peripheral dopamine D1A receptor agonist.[1]

Contents

Mechanism

By activating peripheral D1 receptors, it causes arterial/arteriolar vasodilation leading to a decrease in blood pressure. It is particularly effective in dilating the renal, mesenteric, and coronary arteries, where D1.receptors are found.[2] It decreases afterload and also through specific dopamine receptors along the nephron promoting sodium excretion.citation needed

Uses

Fenoldopam is used as an antihypertensive agent postoperatively, and also via IV to treat hypertensive crisis.[2]

Side effects

Adverse effects include headache, flushing, angina, hypotension, reflex tachycardia, and increased intraocular pressure.[2]

References

  1. ^ Oliver WC, Nuttall GA, Cherry KJ, Decker PA, Bower T, Ereth MH (October 2006). "A comparison of fenoldopam with dopamine and sodium nitroprusside in patients undergoing cross-clamping of the abdominal aorta". Anesth. Analg. 103 (4): 833–40. doi:10.1213/01.ane.0000237273.79553.9e. PMID 17000789. 
  2. ^ a b c Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview, 9. ISBN 1-59541-101-1. 
v • d • e
Antiparkinson drugs: dopaminergic agents (N04B)
Dopa and derivatives
Adamantane derivatives
Dopamine agonists
MAOIs (B)
COMT inhibitors
Other
v • d • e
Cardiac stimulants excluding cardiac glycosides (C01C)
Adrenergic and
dopaminergic agents
α
β
mixed
Fenoldopam
Both
Unknown/ungrouped
Phosphodiesterase inhibitors (PDE3I)
Other cardiac stimulants
Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

  • This page was last modified on 29 September 2008, at 12:06.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Fenoldopam".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.