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Fenoterol
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| Systematic (IUPAC) name | |
| (RS)-1-(3,5-Dihydroxyphenyl)- 2-[(RS)-2-(4-hydroxyphenyl)- 1-methylethylamino]ethanol | |
| Identifiers | |
| CAS number | |
| ATC code | R03 G02 |
| PubChem | |
| Chemical data | |
| Formula | C17H21NO4 |
| Mol. mass | 303.35 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Inhaled |
Fenoterol is an asthma medication designed to open up the airways to the lungs. It is classed as a beta agonist.
Fenoterol was marketed as "Berotec" by Boehringer-Ingelheim.
It was a long-acting beta-agonist widely used in New Zealand in the early 1990s but withdrawn because of its association with an excess number of deaths.
This was due to its additional effects on the B1 receptors that lead to cardiovascular adverse effects, notably dysrhythmia and cardiac hypoxia. Fenoterol increased the risk of death because it was typically used in excessively large doses for severe asthma attacks in the absence of medical assistance. Instances were known of patients who had used up to 80 puffs before seeking medical attention.
References
- Beasley R, Pearce N, Crane J, Burgess C. Withdrawal of fenoterol and the end of the New Zealand asthma mortality epidemic. Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):325-7.
- Spitzer WO, Suissa S, Ernst P, Horwitz RI, Habbick B, Cockcroft D, et al. The use of beta-agonists and the risk of death and near death from asthma. N Engl J Med. 1992 Feb 20, 1992;326(8):501-6.
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Wikipedia content modification information:
- This page was last modified on 4 September 2008, at 00:59.
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