Fibrinogen gamma chain

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Fibrinogen gamma chain
PDB rendering based on 1fib.
Available structures: 1fib, 1fic, 1fid, 1fza, 1fzb, 1fzc, 1fze, 1fzf, 1fzg, 1lt9, 1ltj, 1n86, 1n8e, 1re3, 1re4, 1rf0, 1rf1, 2a45, 2ffd, 2fib, 2h43, 2hod, 2hpc, 2oyh, 2oyi, 3fib
Identifiers
Symbols FGG;
External IDs OMIM: 134850 MGI: 95526 HomoloGene: 429
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2266 99571
Ensembl ENSG00000171557 ENSMUSG00000033860
Uniprot P02679 Q3UEM7
Refseq NM_000509 (mRNA)
NP_000500 (protein)		 NM_133862 (mRNA)
NP_598623 (protein)
Location Chr 4: 155.74 - 155.75 Mb Chr 3: 83.09 - 83.1 Mb
Pubmed search [1] [2]

Fibrinogen gamma chain, also known as FGG, is a human gene.

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.[1]

References

  1. ^ "Entrez Gene: FGG fibrinogen gamma chain".

Further reading

  • Doolittle RF (1984). "Fibrinogen and fibrin.". Annu. Rev. Biochem. 53: 195–229. doi:10.1146/annurev.bi.53.070184.001211. PMID 6383194. 
  • Herrick S, Blanc-Brude O, Gray A, Laurent G (1999). "Fibrinogen.". Int. J. Biochem. Cell Biol. 31 (7): 741–6. PMID 10467729. 
  • Everse SJ (2003). "New insights into fibrin (ogen) structure and function.". Vox Sang. 83 Suppl 1: 375–82. PMID 12617173. 
  • Mosesson MW (2003). "Fibrinogen gamma chain functions.". J. Thromb. Haemost. 1 (2): 231–8. PMID 12871494. 
  • Scott EM, Ariëns RA, Grant PJ (2005). "Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease.". Arterioscler. Thromb. Vasc. Biol. 24 (9): 1558–66. doi:10.1161/01.ATV.0000136649.83297.bf. PMID 15217804. 


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