GABRQ

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gamma-aminobutyric acid (GABA) receptor, theta
Identifiers
Symbol GABRQ
Entrez 55879
HUGO 14454
OMIM 300349
RefSeq NM_018558
UniProt Q9UN88
Other data
Locus Chr. X q28

Gamma-aminobutyric acid (GABA) A receptor, theta, also known as GABRQ, is a human gene.[1][2] The protein encoded by this gene is a subunit of the GABAA receptor.

The θ subunit has highest sequence similarity with the β1 subunit.[2] This subunit coassembles with

  • α2, β1, and γ1[2]
  • α3 and β1[3]
  • α3, β1, and ε[3]

References

  1. ^ Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (May 2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus". J. Neurosci. 20 (10): 3588–95. PMID 10804200. 
  2. ^ a b c Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (August 1999). "theta, a novel gamma-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–6. PMID 10449790. PMC:22306. 
  3. ^ a b Ranna M, Sinkkonen ST, Möykkynen T, Uusi-Oukari M, Korpi ER (2006). "Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes". BMC Pharmacol. 6: 1. doi:10.1186/1471-2210-6-1. PMID 16412217. 

External links

 This membrane protein-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Ion channel, receptor: ligand-gated ion channels
Cys-loop receptors
5-HT3 (A, B, C, D, E)
GABA A (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) • GABA C (ρ1, ρ2, ρ3)
α1 • α2 • α3 • α4 • β
monomers: α1 • α2 • α3 • α4 • α5 • α6 • α7 • α9 • α10 • β1 • β2 • β3 • β4 • δ • ε
pentamers: (α4)2(β2)3 • (α7)5 • (α1)2(β4)3 - Ganglion type • (α1)2β1δε - Muscle type
Ionotropic glutamates
AMPA (1, 2, 3, 4) • Kainate (1, 2, 3, 4, 5)  • NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
ATP-gated channels

Wikipedia content modification information:

  • This page was last modified on 18 August 2008, at 16:58.

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