GABRR1

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Gamma-aminobutyric acid (GABA) receptor, rho 1
Identifiers
Symbols GABRR1; MGC163216
External IDs OMIM: 137161 MGI: 95625 HomoloGene: 20470
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2569 14408
Ensembl ENSG00000146276 ENSMUSG00000028280
Uniprot P24046 P56475
Refseq NM_002042 (mRNA)
NP_002033 (protein)		 NM_008075 (mRNA)
NP_032101 (protein)
Location Chr 6: 89.94 - 89.98 Mb Chr 4: 33.46 - 33.49 Mb
Pubmed search [1] [2]

Gamma-aminobutyric acid (GABA) receptor, rho 1, also known as GABRR1, is a human gene.[1]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.[1]

Contents

See also

References

  1. ^ a b "Entrez Gene: GABRR1 gamma-aminobutyric acid (GABA) receptor, rho 1".

Further reading

  • Cutting GR, Curristin S, Zoghbi H, et al. (1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4.". Genomics 12 (4): 801–6. PMID 1315307. 
  • Cutting GR, Lu L, O'Hara BF, et al. (1991). "Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2673–7. PMID 1849271. 
  • Wang TL, Hackam A, Guggino WB, Cutting GR (1995). "A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors.". J. Neurosci. 15 (11): 7684–91. PMID 7472519. 
  • Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.". J. Biol. Chem. 272 (21): 13750–7. PMID 9153229. 
  • Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.". Neurosci. Lett. 255 (1): 17–20. PMID 9839716. 
  • Hanley JG, Koulen P, Bedford F, et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses.". Nature 397 (6714): 66–9. doi:10.1038/16258. PMID 9892354. 
  • Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.". Biochim. Biophys. Acta 1447 (2-3): 307–12. PMID 10542332. 
  • Hanley JG, Jones EM, Moss SJ (2000). "GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1.". J. Biol. Chem. 275 (2): 840–6. PMID 10625616. 
  • Filippova N, Sedelnikova A, Zong Y, et al. (2000). "Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C.". Mol. Pharmacol. 57 (5): 847–56. PMID 10779366. 
  • Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B.". J. Neurosci. 20 (23): 8643–50. PMID 11102469. 
  • Wang QW, Li ZW, Wang F, Yang JQ (2002). "Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in Xenopus oocytes.". Biomed. Environ. Sci. 14 (4): 269–77. PMID 11862606. 
  • Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor.". Int. J. Dev. Neurosci. 20 (3-5): 237–46. PMID 12175859. 
  • Torres VI, Weiss DS (2003). "Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening.". J. Biol. Chem. 277 (46): 43741–8. doi:10.1074/jbc.M202007200. PMID 12226075. 
  • Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.". J. Biol. Chem. 278 (8): 6128–35. doi:10.1074/jbc.M205162200. PMID 12431995. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Boué-Grabot E, Emerit MB, Toulmé E, et al. (2004). "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels.". J. Biol. Chem. 279 (8): 6967–75. doi:10.1074/jbc.M307772200. PMID 14660627. 
  • Martínez-Torres A, Miledi R (2004). "A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism.". Arch. Med. Res. 35 (3): 194–8. doi:10.1016/j.arcmed.2003.12.002. PMID 15163459. 
  • Sedelnikova A, Smith CD, Zakharkin SO, et al. (2005). "Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model.". J. Biol. Chem. 280 (2): 1535–42. doi:10.1074/jbc.M409908200. PMID 15548535. 
  • Song XQ, Meng F, Ramsey DJ, et al. (2006). "The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina.". Neuroscience 136 (2): 467–75. doi:10.1016/j.neuroscience.2005.08.018. PMID 16198491. 

External links

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v • d • e
Ion channel, receptor: ligand-gated ion channels
Cys-loop receptors
5-HT3 (A, B, C, D, E)
GABA A (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ)
GABA C (ρ1, ρ2, ρ3)
Ionotropic glutamates
AMPA (1, 2, 3, 4)

Kainate (1, 2, 3, 4, 5)

NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
ATP-gated channels

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