Gallamine

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Gallamine
Systematic (IUPAC) name
N-[2-[2,3-bis (2-diethylaminoethoxy) phenoxy]ethyl]- N-ethyl-ethanamine
Identifiers
CAS number 65-29-2
ATC code M03AC02
PubChem 67425
DrugBank APRD00712
Chemical data
Formula C24H45N3O3
C30H60N3O3+3 · 3 I- (gallamine triethiodide)
Mol. mass 423.633 g/mol
891.529 g/mol (triethiodide)
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Gallamine (as gallamine triethiodide) is a non-depolarising muscle relaxant. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release.

Gallamine is commonly used to stabilize muscle contractions during surgical procedures.

v • d • e
Skeletal Muscle relaxants (M03)
Peripherally acting
(primarily antinicotinic,
NMJ blocking)
Centrally acting
Other
Directly acting
Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

  • This page was last modified on 17 July 2008, at 20:15.

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