Gi subunit

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Identifiers
Symbol GNAI1
Entrez 2770
HUGO 4384
OMIM 139310
RefSeq NM_002069
UniProt P63096
Other data
Locus Chr. 7 q21-q22
Identifiers
Symbol GNAI2
Alt. Symbols GNAI2B
Entrez 2771
HUGO 4385
OMIM 139360
RefSeq NM_002070
UniProt P04899
Other data
Locus Chr. 3 p21
Identifiers
Symbol GNAI3
Entrez 2773
HUGO 4387
OMIM 139370
RefSeq NM_006496
UniProt P08754
Other data
Locus Chr. 1 p13

Gi alpha subunit (or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit which inhibits the production of cAMP from ATP.[1]

Contents

Receptors

The following G-protein coupled receptors couple to the Gi subunit:

Function

See also: function of cAMP-dependent protein kinase

Gi inhibits the production of cAMP from ATP, which, in turn, results in decreased activity of cAMP-dependent protein kinase. Thus, the ultimate effect of Gi is thus the opposite of cAMP-dependent protein kinase, which can be found at function of cAMP-dependent protein kinase.

Types

There are several types of Gi: Gia1, Gia2, Gia3 and Gia4

Gia1

Gia1 or Gi1 is encoded by the gene GNAI1.

Gia2

Gia2 or Gi2 is encoded by the gene GNAI2.

Gia3

Gia3 or Gi3 is encoded by the gene GNAI3.

See also

References

  1. ^ Birnbaumer L (April 2007). "Expansion of signal transduction by G proteins. The second 15 years or so: from 3 to 16 alpha subunits plus betagamma dimers". Biochim. Biophys. Acta 1768 (4): 772–93. doi:10.1016/j.bbamem.2006.12.002. PMID 17258171. 

External links

 This biochemistry article is a stub. You can help Wikipedia by expanding it.
v • d • e
Acid anhydride hydrolases: GTPases/G proteins (EC 3.6.5)
3.6.5.1: Heterotrimeric G protein
3.6.5.2: Small GTPase > Ras superfamily
3.6.5.3: Elongation factor
3.6.5.5-6: Other
Dynamin (is a GTPase, is not a G protein) - Tubulin

Wikipedia content modification information:

  • This page was last modified on 31 August 2008, at 13:03.

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