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Glaucine
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| Systematic (IUPAC) name | |
| (S)-5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline | |
| Identifiers | |
| CAS number | 5630-11-5 |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C21H25NO4 |
| Mol. mass | 355.428 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Glaucine is an alkaloid found in several different plant species such as Glaucium flavum, Glaucium oxylobum,[1] Croton lechleri[2] and Corydalis yanhusuo.[3] It has bronchodilator and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker,[4] and is used medically as an antitussive in some countries.[5] Glaucine may produce side effects such as sedation, fatigue, and a hallucinogenic effect characterised by colourful visual images,[6][7] and has recently been detected as a novel recreational drug.[8]
See Also
References
- ^ Morteza-Semnani K, Amin G, Shidfar MR, Hadizadeh H, Shafiee A. Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum. Fitoterapia. 2003 Jul;74(5):493-6. PMID 12837370
- ^ Milanowski DJ, Winter RE, Elvin-Lewis MP, Lewis WH. Geographic distribution of three alkaloid chemotypes of Croton lechleri. Journal of Natural Products. 2002 Jun;65(6):814-9. PMID 12088421
- ^ Xu XH, Yu GD, Wang ZT. Resource investigation and quality evaluation on wild Corydalis yanhusuo. (Chinese). Zhongguo Zhong Yao Za Zhi. 2004 May;29(5):399-401. PMID 15706885
- ^ Cortijo J, Villagrasa V, Pons R, Berto L, Martí-Cabrera M, Martinez-Losa M, Domenech T, Beleta J, Morcillo EJ. Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes. British Journal of Pharmacology. 1999 Aug;127(7):1641-51. PMID 10455321
- ^ Rühle KH, Criscuolo D, Dieterich HA, Köhler D, Riedel G. Objective evaluation of dextromethorphan and glaucine as antitussive agents. British Journal of Clinical Pharmacology. 1984 May;17(5):521-4. PMID 6375709
- ^ Rovinskiĭ VI. A case of hallucinogen-like action of glaucine. (Russian). Klinicheskaia Meditsina (Mosk). 1989 Sep;67(9):107-8. PMID 2586025
- ^ Rovinskiĭ VI. Acute glaucine syndrome in the physician's practice: the clinical picture and potential danger. (Russian). Klinicheskaia Meditsina (Mosk). 2006;84(11):68-70. PMID 17243616
- ^ Dargan PI, Button J, Hawkins L, Archer JR, Ovaska H, Lidder S, Ramsey J, Holt DW, Wood DM. Detection of the pharmaceutical agent glaucine as a recreational drug. European Journal of Clinical Pharmacology. 2008 May;64(5):553-4. PMID 18204834
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Wikipedia content modification information:
- This page was last modified on 2 October 2008, at 23:49.
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