Glycoprotein IIb/IIIa

This MedLibrary.org supplementary page on Glycoprotein IIb/IIIa is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

Identifiers
Symbol ITGA2B
Alt. Symbols GP2B
Entrez 3674
HUGO 6138
OMIM 607759
RefSeq NM_000419
UniProt P08514
Other data
Locus Chr. 17 q21.32
Identifiers
Symbol ITGB3
Alt. Symbols GP3A
Entrez 3690
HUGO 6156
OMIM 173470
RefSeq NM_000212
UniProt P05106
Other data
Locus Chr. 17 q21.32

In medicine, glycoprotein IIb/IIIa, also gpIIb/IIIa, is an integrin found on platelets. Calcium-dependent association of gpIIb and gpIIIa is required for normal platelet aggregation and endothelial adherence.[1][2]

Contents

Pathology

Defects in glycoprotein IIb/IIIa causes Glanzmann's thrombasthenia.[3]

Medicine

Glycoprotein IIb/IIIa inhibitors can be used to prevent blood clots in an effort to decrease the risk of heart attack or stroke.

See also

References

  1. ^ Calvete JJ (1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208 (4): 346–60. PMID 7535429. 
  2. ^ Shattil SJ (1999). "Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways". Thromb. Haemost. 82 (2): 318–25. PMID 10605720. 
  3. ^ Bellucci S, Caen J (2002). "Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment". Blood Rev. 16 (3): 193–202. doi:10.1016/S0268-960X(02)00030-9. PMID 12163005. 

External links

 This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.
v • d • e
Membrane proteins: cell adhesion molecules
IgSF
Cadherins
Selectins
Integrins
LFA-1 - Integrin alphaXbeta2 - Macrophage-1 antigen - VLA-4 - Glycoprotein IIb/IIIa (Note: integrins not always classified as CAMs)
Other

Wikipedia content modification information:

  • This page was last modified on 5 May 2008, at 23:55.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Glycoprotein IIb/IIIa".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.