This MedLibrary.org supplementary page on Gq alpha subunit is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
| Identifiers | |
| Symbol | GNAQ |
| Entrez | 2776 |
| HUGO | 4390 |
| OMIM | 600998 |
| RefSeq | NM_002072 |
| UniProt | P50148 |
| Other data | |
| Locus | Chr. 9 q21 |
| Identifiers | |
| Symbol | GNA11 |
| Entrez | 2767 |
| HUGO | 4379 |
| OMIM | 139313 |
| RefSeq | NM_002067 |
| UniProt | P29992 |
| Other data | |
| Locus | Chr. 19 p13.3 |
|
guanine nucleotide binding protein (G protein), alpha 14
|
|
| Identifiers | |
| Symbol | GNA14 |
| Entrez | 9630 |
| HUGO | 4382 |
| OMIM | 604397 |
| RefSeq | NM_004297 |
| UniProt | O95837 |
| Other data | |
| Locus | Chr. 9 q21 |
|
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
|
|
| Identifiers | |
| Symbol | GNA15 |
| Entrez | 2769 |
| HUGO | 4383 |
| OMIM | 139314 |
| RefSeq | NM_002068 |
| UniProt | P30679 |
| Other data | |
| Locus | Chr. 19 p13.3 |
Gq protein or Gq/11 is a heterotrimeric G protein subunit that activates phospholipase C (PLC). PLC in turn hydrolyzes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3) signal transduction pathway. DAG acts as a second messenger that activates Protein Kinase C (PKC) and IP3 helps in phosphorylation of some proteins.
Contents |
Function
Gq proteins are class of G proteins which work to activate phospholipase C (PLC), participating in a varity of cellular signaling pathways, including taste, manic depression, tumor promotion, etc.[1]
The Gq protein works by activating PLC. PLC then cleaves a phospholipid. In the process, phosphatidylinositol 4,5-bisphosphate (PIP2) is cleaved into diacyl glycerol (DAG) and inositol 1,4,5-triphosphate (IP3). DAG remains on bound to the membrane, and IP3 is released as a soluble structure into the cytosol. IP3 then diffuses through the cytosol to bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). These channels are specific to calcium and only allow the passage of calcium to move through. This causes the cytosolic concentration of Calcium to increase, causing a cascade of intracellular changes and activity.[1]
- Further reading:Calcium function in humans
In addition, calcium and DAG together works to activate PKC, which goes on to phosphorylate other things, leading to altered cellular activity.[1]
- Further reading:function of protein kinase C
Examples of GPCR partners
From modulatory neurotransmitter receptors (amine receptors belonging to rhodopsin family), Gq is usually coupled to e.g. the G-protein coupled receptors:
- Alpha 1 adrenergic receptors
- 5-HT receptor type 2
- Muscarinic receptors 1, 3 and 5
- Histamine receptor type 1
- Calcitonin receptor
Genes
See also
References
- ^ a b c Alberts B, Lewis J, Raff M, Roberts K, Walter P (2002). Molecular biology of the cell, 4th Edition, New York: Garland Science. ISBN 0-8153-3218-1.
External links
 |
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
|
||||||||||||||
Wikipedia content modification information:
- This page was last modified on 6 May 2008, at 18:42.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Gq alpha subunit".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.