Growth hormone releasing hormone

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Growth hormone releasing hormone
Identifiers
Symbol GHRH
Alt. Symbols GRF, GHRF
Entrez 2691
HUGO 4265
OMIM 139190
RefSeq NM_021081
UniProt P01286
Other data
Locus Chr. 20 p12 or q11.2-q12

Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus.

GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophyseal portal circulation to the anterior pituitary gland where it stimulates growth hormone (GH) secretion. GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH. In addition, GHRH also promotes slow-wave sleep directly. [1]

Relationship of GRH & somatostatin

The actions of GHRH are opposed by "growth-hormone-inhibiting hormone", more commonly termed somatostatin.

Somatostatin is released from neurosecretory nerve terminals of periventricular somatostatin neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary where it inhibits GH secretion. Somatostatin and GHRH are secreted in alternation, giving rise to the markedly pulsatile secretion of GH.

Sequence

The amino acid sequence of GHRH is:

Tyr - Ala - Asp - Ala - Ile - Phe - Thr - Asn - Ser - Tyr - Arg - Lys - Val - Leu - Gly - Glu - Leu - Ser - Ala - Arg - Lys - Leu - Leu - Gln - Asp - Ile - Met - Ser - Arg - Glu - Gln - Gly - Glu - Ser - Asn - Gln - Glu - Arg - Gly - Ala - Arg - Ala - Arg - LeuNH2

References

  1. ^ Obál F, Krueger J (2001). "The somatotropic axis and sleep.". Rev Neurol (Paris) 157 (11 Pt 2): S12–5. PMID 11924022. 
v • d • e
Endocrine system: hormones/endocrine glands (Peptide hormones, Steroid hormones)
Hypothalamic-pituitary
Adrenal axis
Thyroid axis
Gonadal axis
Other end. glands
Non-end. glands
Target-derived
v • d • e
Peptides: neuropeptides
Hypothalamic
Gastrointestinal hormones
Other hormones
Other
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  • This page was last modified on 28 May 2008, at 11:30.

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