This MedLibrary.org supplementary page on Guanylyl cyclase c is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
|
guanylate cyclase 2C (heat stable enterotoxin receptor)
|
|
| Identifiers | |
| Symbol | GUCY2C |
| Alt. Symbols | GUC2C |
| Entrez | 2984 |
| HUGO | 4688 |
| OMIM | 601330 |
| RefSeq | NM_004963 |
| UniProt | P25092 |
| Other data | |
| EC number | 4.6.1.2 |
| Locus | Chr. 12 p12 |
Guanylyl cyclase c, or GC-C, is an enzyme found only in the luminal aspect of intestinal epithelium. The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylyl cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.
Contents |
Functions
GC-C is a key receptor for heat-stable enterotoxins which are responsible for acute secretory diarrhea. Heat-stable enterotoxins are produced by pathogens such as Escherichia coli. Knockout mice defficient in the GC-C gene do not show secretory diarrhea on infection with E. coli, though they do with cholera toxin. This demonstrates the specificity of the GC-C receptor.
Diagnostic application
Because GC-C is tissue-specific for intestinal epithelium, it can be used for exceedingly precise detection of metastatic disease. The presence of GC-C mRNA can be detected at a rate of a single cancer cell out of 10,000,000 normal cells. This is the most precise staging tool available.
See also
External links
|
|||||
Wikipedia content modification information:
- This page was last modified on 21 August 2007, at 19:19.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Guanylyl cyclase c".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.