HHIP

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Hedgehog interacting protein
Identifiers
Symbols HHIP; HIP; FLJ20992; FLJ90230
External IDs OMIM: 606178 MGI: 1341847 HomoloGene: 32469
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 64399 15245
Ensembl ENSG00000164161 ENSMUSG00000064325
Uniprot Q96QV1 Q7TN16
Refseq NM_022475 (mRNA)
NP_071920 (protein)		 NM_020259 (mRNA)
NP_064655 (protein)
Location Chr 4: 145.79 - 145.88 Mb Chr 8: 82.87 - 82.95 Mb
Pubmed search [1] [2]

Hedgehog interacting protein, also known as HHIP, is a human gene.[1]

This gene encodes a protein similar to the mouse hedgehog-interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.[1]

References

  1. ^ a b "Entrez Gene: HHIP hedgehog interacting protein".

Further reading

  • Ingham PW, McMahon AP (2001). "Hedgehog signaling in animal development: paradigms and principles.". Genes Dev. 15 (23): 3059–87. doi:10.1101/gad.938601. PMID 11731473. 
  • Chuang PT, McMahon AP (1999). "Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein.". Nature 397 (6720): 617–21. doi:10.1038/17611. PMID 10050855. 
  • Bak M, Hansen C, Friis Henriksen K, Tommerup N (2001). "The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3.". Cytogenet. Cell Genet. 92 (3-4): 300–3. PMID 11435703. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Olsen CL, Hsu PP, Glienke J, et al. (2004). "Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors.". BMC Cancer 4: 43. doi:10.1186/1471-2407-4-43. PMID 15294024. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kayed H, Kleeff J, Esposito I, et al. (2005). "Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas.". Mol. Carcinog. 42 (4): 183–92. doi:10.1002/mc.20088. PMID 15754313. 
  • Martin ST, Sato N, Dhara S, et al. (2006). "Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms.". Cancer Biol. Ther. 4 (7): 728–33. PMID 15970691. 
 This article on a gene on chromosome 4 is a stub. You can help Wikipedia by expanding it.


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Signaling pathway: hedgehog signaling pathway
Ligands
Other
PTCH1 · Smoothened · GLI1 · GLI2 · GLI3 · HHIP · HHAT

Wikipedia content modification information:

  • This page was last modified on 9 September 2008, at 01:14.

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