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| Haemophilia B Classification and external resources |
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| ICD-10 | D67. |
|---|---|
| ICD-9 | 286.1 |
| OMIM | 306900 |
| DiseasesDB | 5561 |
| MedlinePlus | 000539 |
| eMedicine | emerg/240 |
| MeSH | D002836 |
Haemophilia B (also spelled Hemophilia B or Hæmophilia B) is a blood clotting disorder caused by a mutation of the Factor IX gene, leading to a deficiency of Factor IX. It is the least common form of haemophilia, rarer than haemophilia A. It is sometimes called Christmas disease after Stephen Christmas, the first patient described with this disease.[1] In addition, the first report of its identification was published in the Christmas edition of the British Medical Journal.[2]
Contents |
Treatment
Treatment (bleeding prophylaxis) is by intravenous infusion of factor IX. Factor IX has a longer half life than factor VIII (Deficient in Haemophilia A) and as such factor IX can be transfused less frequently.
Genetics
The factor IX gene is located on the X chromosome (Xq27.1-q27.2). It is an X-linked recessive trait, which explains why, as in haemophilia A, only males are usually affected.
Pathophysiology
Factor IX deficiency leads to an increased propensity for haemorrhage. This is in response to mild trauma or even spontaneously, such as in joints (haemarthrosis) or muscles.
References
- ^ Christmas' disease at Who Named It
- ^ Biggs R, Douglas AS, MacFarlane RG, Dacie JV, Pitney WR, Merskey C, O'Brien JR (1952). "Christmas disease: a condition previously mistaken for haemophilia". Br Med J 2 (4799): 1378–82. PMID 12997790.
See also
External links
- Haemophilia: What is it? at CSHL Your Genes, Your Health
- haemophilia B at GPnotebook
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Wikipedia content modification information:
- This page was last modified on 14 August 2008, at 02:42.
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