Haplogroup L4 (mtDNA)

Haplogroup L4
Time of origin
Place of origin East Africa
Ancestor L3'4
Descendants L4a, L4b
Defining mutations 5460, 16362[1]

In human mitochondrial genetics, Haplogroup L4 is a human mitochondrial DNA (mtDNA) haplogroup.

It is a small African haplogroup.[2]

Contents

Origin

Distribution

L4 is important in East Africa and Horn of Africa. The highest frequencies are in Tanzania among the Hadza at 60-83% and Sandawe at 48%.[3]

Subclades

Tree

This phylogenetic tree of haplogroup L4 subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[1] and subsequent published research.

  • L3'4
    • L4
      • L4a or L7
        • L4a1
        • L4a1a
        • L4a2
      • L4b
        • L4b1
        • L4b2 or L4g (formerly L3g)
          • L4b2a
            • L4b2a1
            • L4b2a2
              • L4b2a2a
              • L4b2a2b
                • L4b2a2b1
          • L4b2b

References

  1. ^ a b van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation 30 (2): E386-E394. PMID 18853457 doi:10.1002/humu.20921. http://www3.interscience.wiley.com/journal/121449735/abstract?CRETRY=1&SRETRY=0. Retrieved 2009-05-20. 
  2. ^ Haplogroups L4.
  3. ^ Tishkoff, S. et al. 2007, History of Click-Speaking Populations of Africa Inferred from mtDNA and Y Chromosome Genetic Variation. Molecular Biology and Evolution 2007 24(10):2180-2195

Human mitochondrial DNA (mtDNA) haplogroups
  Mitochondrial Eve (L)    
L0 L1 L2 L3   L4 L5 L6
  M N  
CZ D E G Q   A S   R   I W X Y
C Z B F R0   pre-JT P  U
HV JT K
H V J T Former Clusters IWX

External links


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This page was last modified on 2 February 2010 at 13:36.

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