Hesperidin

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Hesperidin
Identifiers
CAS number [520-26-3]
PubChem 10621
Properties
Molecular formula C28H34O15
Molar mass 610.56056
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox references

Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin. Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies.[1] In human nutrition it contributes to the integrity of the blood vessels.

Various preliminary studies reveal novel pharmaceutical properties. Hesperidin reduced cholesterol[2] and blood pressure[3] in rats. In a mouse study large doses of the glucoside hesperidin decreased bone density loss.[4] Another animal study showed protective effects against sepsis.[5] Hesperitin has anti-inflammatory effects.[6][7]

Some in vitro results applied only to the aglucone form. Hesperitin also showed the ability to penetrate the blood brain barrier in an in vitro model.[8]

References

  1. ^ Kinetics of radical-scavenging activity of hespere...[Anticancer Res. 2005 Sep-Oct] - PubMed Result
  2. ^ Biological effects of hesperidin, a Citrus flavono...[Farmaco. 1995] - PubMed Result
  3. ^ Glucosyl hesperidin improves serum cholesterol com...[J Nutr Sci Vitaminol (Tokyo). 2003] - PubMed Result
  4. ^ Hesperidin, a citrus flavonoid, inhibits bone loss...[J Nutr. 2003] - PubMed Result
  5. ^ A citrus flavonoid hesperidin suppresses infection...[Biol Pharm Bull. 2004] - PubMed Result
  6. ^ Pharmacological evaluation of the anti-inflammator...[J Pharm Pharmacol. 1994] - PubMed Result
  7. ^ Biological effects of hesperidin, a citrus flavono...[Farmaco. 1994] - PubMed Result
  8. ^ Interaction between flavonoids and the blood-brain...[J Neurochem. 2003] - PubMed Result
v • d • e
Glycosides
Bond:
Geometry:
Glycone:
Aglycone:
Major families of biochemicals
Saccharides | Carbohydrates | Glycosides | | Amino acids | Peptides | Proteins | Glycoproteins | | Lipids | Terpenes | Steroids | Carotenoids
Alkaloids | Nucleobases | Nucleic acids | | Enzyme cofactors | Flavonoids | Polyketides | Tetrapyrroles

Wikipedia content modification information:

  • This page was last modified on 7 July 2008, at 12:21.

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