This MedLibrary.org supplementary page on Hypoxanthine is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
| Hypoxanthine | |
|---|---|
 |
|
| IUPAC name | 3,7-dihydropurin-6-one |
| Identifiers | |
| CAS number | [68-94-0] |
| PubChem | |
| MeSH | |
| SMILES |
|
| Properties | |
| Molecular formula | C5H4N4O |
| Molar mass | 136.112 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
|
Hypoxanthine is a naturally occurring purine derivative. It is occasionally found as a constituent of nucleic acids where it is present in the anticodon of tRNA in the form of its nucleoside inosine. It is also known as 6-Hydroxypurine. Hypoxanthine is a necessary additive in certain cell, bacteria and parasite cultures as a substrate and nitrogen source. For example it is commonly a required reagent in malaria parasite cultures since Plasmodium falciparum requires a source of hypoxanthine for nucleic acid synthesis and energy metabolism.
Reactions
It is one of the products of the action of xanthine oxidase on xanthine, though more normally in purine degradation, hypoxanthine is formed from oxidation of xanthine by xanthine oxidase.
Hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in nucleotide salvage.
Hypoxanthine is also a spontaneous deamination product of adenine. Because of its resemblance to guanine, the spontaneous deamination of adenine can lead to an error in DNA transcription/replication.
Additional images
 Adenine. Notice the extra nitrogen compared to the oxygen in hypoxanthine. (Disregard the fact that the rings are in opposite positions.) |
External links
 |
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
|
|||||||||||||||||||||
Wikipedia content modification information:
- This page was last modified on 12 June 2008, at 16:03.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Hypoxanthine".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.