|
Transcription factors and intracellular receptors |
|
|
(1) Basic domains |
|
|
|
Activating transcription factor ( AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 ( c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH ( 1, 2) • BATF • BLZF1 • C/EBP ( α, β, γ, δ, ε, ζ) • CREB ( 1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF ( B, F, G, K) • NFE ( 2, L1, L2) • NRL • NRF1 • XBP1
|
|
(1.2) Basic helix-loop-helix ( bHLH)
|
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL ( ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND ( 1, 2) • HES ( 5, 6) • HEY ( 1, 2, L) • HES1 • HIF ( 1A, 3A) • ID ( 1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors ( MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD ( 1, 2) • NPAS ( 1, 2, 3) • OLIG ( 1, 2) • Pho4 • Scleraxis • TAL1 • Twist • USF1
|
|
|
|
|
|
|
(1.4) NF-1
|
|
|
|
(1.5) RF-X
|
|
|
|
(1.6) Basic helix-span-helix (bHSH)
|
|
|
|
|
|
(2) Zinc finger DNA-binding domains |
|
|
|
subfamily 1 ( Thyroid hormone ( α, β), CAR, FXR, LXR ( α, β), PPAR ( α, β/δ, γ), PXR, RAR ( α, β, γ), ROR ( α, β, γ), Rev-ErbA ( α, β), VDR)
subfamily 2 ( COUP-TF ( I, II), Ear-2, HNF4 ( α, γ), PNR, RXR ( α, β, γ), Testicular receptor ( 2, 4), TLX)
subfamily 3 ( Steroid hormone ( Androgen, Estrogen ( α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related ( α, β, γ))
subfamily 4 NUR ( NGFIB, NOR1, NURR1) • subfamily 5 ( LRH-1, SF1) • subfamily 6 ( GCNF) • subfamily 0 ( DAX1, SHP)
|
|
|
(2.2) Other Cys4
|
|
|
|
(2.3) Cys2His2
|
General transcription factors ( TFIIA, TFIIB, TFIID, TFIIE, TFIIF ( 1, 2), TFIIH ( 1, 2, 4, 2I, 3A, 3C1, 3C2))
ATBF1 • BCL ( 6, 11A, 11B) • CTCF • E4F1 • EGR ( 2, 3) • ERV3 • GFI1 • GLI-Krüppel family ( 1, 2, 3, S2, YY1) • HIC ( 1, 2) • HIVEP ( 1, 2, 3) • IKZF ( 1, 2, 3) • ILF ( 2, 3) • KLF ( 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17 ) • MTF1 • MYT1 • OSR1 • SP ( 1, 2, 4, 7) • Zbtb7 ( 7A, 7B) • ZBTB ( 16, 17, 20, 32, 33, 40) • zinc finger ( 3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 649, 655)
|
|
|
(2.4) Cys6
|
|
|
|
(2.5) Alternating composition
|
|
|
|
|
|
(3) Helix-turn-helix domains |
|
|
|
ARX • CDX ( 1, 2) • CRX • CUTL1 • DLX ( 3, 4, 5) • EMX2 • EN ( 1, 2) • FHL ( 1, 2, 3) • HESX1 • HHEX • HLX • Homeobox ( A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS ( 1, 2) • MEOX2 • MNX1 • MSX ( 1, 2) • NANOG • NKX ( 2-1, 2-2, 2-3, 2-5, 3-1, 3-2) • PBX ( 1, 2, 3) • PHF ( 1, 3, 6, 8, 10, 16, 17, 20, 21A) • PITX ( 1, 2, 3) • POU domain ( PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) • OTX ( 1, 2) • PDX1
|
|
|
(3.2) Paired box
|
|
|
|
|
E2F ( 1, 2, 3, 4, 5) • FOX proteins ( C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, O3A, O4, P1, P2, P3)
|
|
|
|
|
|
|
(3.5) Tryptophan clusters
|
ELF ( 4, 5) • EGF • ELK ( 1, 3, 4) • ERF • ERG • ETS ( 1, 2, SPIB) • ETV ( 1, 4, 5, 6) • FLI1 • Interferon regulatory factors ( 1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
|
|
|
(3.6) TEA domain
|
transcriptional enhancer factor ( 1, 2, 3, 4)
|
|
|
|
|
(4) β-Scaffold factors with minor groove contacts |
|
|
|
|
|
|
|
|
|
|
(4.3) p53
|
|
|
|
|
|
|
|
|
|
|
|
|
HMGB ( 1, 2, 3) • HNF ( 1A, 1B) • LEF1 • SOX ( 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) • SRY • SSRP1 • TCF ( 3, 4) • TOX ( 1, 2, 3, 4)
|
|
|
(4.10) Cold-shock domain
|
|
|
|
(4.11) Runt
|
|
|
|
|
|
(0) Other transcription factors |
|
|
(0.2) HMGI(Y)
|
|
|
|
|
|
|
|
|
|
|
|
(0.6) Miscellaneous
|
ARID ( 1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI ( 16, 35) • MLL ( 2, 3, T1) • MNDA • NFY ( A, B, C) • Rho/ Sigma
|
|
|
|
