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Interleukin 2 receptor, alpha, also known as IL2RA, is a human gene.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown.[1]
References
Further reading
- Kuziel WA, Greene WC (June 1990). "Interleukin-2 and the IL-2 receptor: new insights into structure and function". J. Invest. Dermatol. 94 (6 Suppl): 27S–32S. PMID 1693645. Retrieved on 2008-08-04.
- Waldmann TA (February 1991). "The interleukin-2 receptor". J. Biol. Chem. 266 (5): 2681–4. PMID 1993646. Retrieved on 2008-08-04.
- Murakami S (September 2004). "Soluble interleukin-2 receptor in cancer". Front. Biosci. 9: 3085–90. PMID 15353339. Retrieved on 2008-08-04.
- Vincenti F (September 2004). "Interleukin-2 receptor antagonists and aggressive steroid minimization strategies for kidney transplant patients". Transpl. Int. 17 (8): 395–401. doi:. PMID 15365604. Retrieved on 2008-08-04.
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