IL2RB

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Interleukin 2 receptor, beta
PDB rendering based on 2b5i.
Available structures: 2b5i, 2erj
Identifiers
Symbols IL2RB; CD122; P70-75
External IDs OMIM: 146710 MGI: 96550 HomoloGene: 47955
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3560 16185
Ensembl ENSG00000100385 ENSMUSG00000068227
Uniprot P14784 Q3TEQ2
Refseq NM_000878 (mRNA)
NP_000869 (protein)		 NM_008368 (mRNA)
NP_032394 (protein)
Location Chr 22: 35.85 - 35.88 Mb Chr 15: 78.31 - 78.32 Mb
Pubmed search [1] [2]

Interleukin 2 receptor, beta, also known as IL2RB, is a human gene.[1]

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.[1]

See also

References

  1. ^ a b "Entrez Gene: IL2RB interleukin 2 receptor, beta".

Further reading

  • Ellery JM, Nicholls PJ (2002). "Alternate signalling pathways from the interleukin-2 receptor.". Cytokine Growth Factor Rev. 13 (1): 27–40. PMID 11750878. 
  • Purvis SF, Georges DL, Williams TM, Lederman MM (1992). "Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein.". Cell. Immunol. 144 (1): 32–42. PMID 1394441. 
  • Torigoe T, Saragovi HU, Reed JC (1992). "Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line.". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2674–8. PMID 1557373. 
  • Maslinski W, Remillard B, Tsudo M, Strom TB (1992). "Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol.". J. Biol. Chem. 267 (22): 15281–4. PMID 1639773. 
  • Miyazaki T, Maruyama M, Yamada G, et al. (1991). "The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction.". EMBO J. 10 (11): 3191–7. PMID 1915291. 
  • Shibuya H, Yoneyama M, Nakamura Y, et al. (1990). "The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment.". Nucleic Acids Res. 18 (13): 3697–703. PMID 1973832. 
  • Hatakeyama M, Kono T, Kobayashi N, et al. (1991). "Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association.". Science 252 (5012): 1523–8. PMID 2047859. 
  • Mills GB, May C, McGill M, et al. (1990). "Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated.". J. Biol. Chem. 265 (6): 3561–7. PMID 2303462. 
  • Oyaizu N, Chirmule N, Kalyanaraman VS, et al. (1990). "Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA.". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2379–83. PMID 2315327. 
  • Gnarra JR, Otani H, Wang MG, et al. (1990). "Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.". Proc. Natl. Acad. Sci. U.S.A. 87 (9): 3440–4. PMID 2333293. 
  • Tsudo M, Kitamura F, Miyasaka M (1989). "Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.". Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1982–6. PMID 2467293. 
  • Hatakeyama M, Tsudo M, Minamoto S, et al. (1989). "Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.". Science 244 (4904): 551–6. PMID 2785715. 
  • Kornfeld H, Cruikshank WW, Pyle SW, et al. (1988). "Lymphocyte activation by HIV-1 envelope glycoprotein.". Nature 335 (6189): 445–8. doi:10.1038/335445a0. PMID 2843775. 
  • Leonard WJ, Donlon TA, Lebo RV, Greene WC (1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.". Science 228 (4707): 1547–9. PMID 3925551. 
  • Bamborough P, Hedgecock CJ, Richards WG (1995). "The interleukin-2 and interleukin-4 receptors studied by molecular modelling.". Structure 2 (9): 839–51. PMID 7529123. 
  • Minami Y, Nakagawa Y, Kawahara A, et al. (1995). "Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway.". Immunity 2 (1): 89–100. PMID 7600304. 
  • Giri JG, Kumaki S, Ahdieh M, et al. (1995). "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.". EMBO J. 14 (15): 3654–63. PMID 7641685. 
  • Kirken RA, Rui H, Evans GA, Farrar WL (1993). "Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit.". J. Biol. Chem. 268 (30): 22765–70. PMID 7693677. 
  • Puri RK, Leland P, Aggarwal BB (1995). "Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line.". AIDS Res. Hum. Retroviruses 11 (1): 31–40. PMID 7734194. 
  • Miyazaki T, Liu ZJ, Kawahara A, et al. (1995). "Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation.". Cell 81 (2): 223–31. PMID 7736574. 
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