Idoxuridine

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Idoxuridine
Systematic (IUPAC) name
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]- 5-iodo-pyrimidine-2,4-dione
Identifiers
CAS number 54-42-2
ATC code D06BB01 J05AB02, S01AD01
PubChem 5905
DrugBank APRD00504
Chemical data
Formula C9H11IN2O5 
Mol. mass 354.099 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes intravenously

Idoxuridine is an anti-herpesvirus antiviral drug.

It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing.

External links

  • Seth A, Misra A, Umrigar D (2004). "Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.". Pharm Dev Technol 9 (3): 277–89. doi:10.1081/PDT-200031432. PMID 15458233. 
  • Otto S. "Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine).". J Intraven Nurs 21 (6): 335–7. PMID 10392098. 
  • Fauth E, Zankl H (1999). "Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting.". Mutat Res 440 (2): 147–56. PMID 10209337. 


v • d • e
Antibiotics and chemotherapeutics for dermatological use (D06)
Antibiotics
Tetracycline and derivatives
Others
Chemotherapeutics
Other
v • d • e
Antivirals, other than for HIV (primarily J05, also S01AD and D06BB)
Anti-herpesvirus (DNA, I)
HPV/MC (DNA, I)
Hepatitis B (DNA, VII)
Hepatitis C (RNA, IV)
Picornavirus (RNA, IV)
Anti-influenza agents (RNA, V)
HIV (Reverse, VI)
Other antiviral agents
general (Inosine, Interferon)
†Undergoing clinical trials, not FDA approved.
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Wikipedia content modification information:

  • This page was last modified on 31 May 2008, at 14:28.

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