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Ifosfamide
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| Systematic (IUPAC) name | |
| 3-(2-chloroethyl)-2 -[(2-chloroethyl)amino]tetrahydro -2H-1,3,2-oxazaphosphorine 2-oxide |
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| Identifiers | |
| CAS number | |
| ATC code | L01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C7H15Cl2N2O2P |
| Mol. mass | 261.1 |
| Pharmacokinetic data | |
| Bioavailability | 100% |
| Metabolism | Hepatic |
| Half life | 60-80% in 72 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
? |
| Routes | intravenously |
Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer. It is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous, and is given as a treatment for a variety of cancers, including:
- Testicular cancer
- Breast cancer
- Lymphoma (Non-Hodgkin)
- Soft tissue sarcoma
- Osteogenic sarcoma
- Lung cancer
- Cervical cancer
- Ovarian cancer
- Bone cancer
Ifosfamide is often used in conjunction with Mesna to avoid internal bleeding in the patient, in particular hemorrhagic cystitis.
External links
- ACS Drug Guide: Ifosfamide
- Harvard Medical School Health Information on Ifosfamide
- MedlinePlus Drug Information
- BC Cancer Agency Ifosamide Information (Professional)
- RxList Online Drug Index Ifosamide Listing
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Wikipedia content modification information:
- This page was last modified on 16 June 2008, at 14:28.
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