Importin

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PDB Molecule of the Month pdb85_1

Importin is a type of protein that moves other protein molecules into the nucleus by binding to a specific recognition sequence, called the nuclear localization signal (NLS). Importin is classified as a karyopherin.12

Importin has two subunits, importin α and importin β. Of these, importin α binds to the NLS of the protein to be imported to the nucleus whereas importin β helps in the docking of the importin heterodimer-bound protein to the nuclear pore complex. The NLS-Importin α-Importin β trimer dissociates after binding to Ran GTP inside the nucleus.3

Genes

References

  1. ^ http://big.mcw.edu/display.php/1053.html
  2. ^ Görlich D, Prehn S, Laskey RA, Hartmann E (1994). "Isolation of a protein that is essential for the first step of nuclear protein import". Cell 79 (5): 767–78. doi:10.1016/0092-8674(94)90067-1. PMID 8001116. 
  3. ^ Mattaj IW, Englmeier L (1998). "Nucleocytoplasmic transport: the soluble phase". Annu. Rev. Biochem. 67: 265–306. doi:10.1146/annurev.biochem.67.1.265. PMID 9759490. 

External links

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Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
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C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
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Wikipedia content modification information:

  • This page was last modified on 28 March 2008, at 15:11.

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