Inositol triphosphate receptor

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inositol 1,4,5-triphosphate receptor, type 1
Identifiers
Symbol ITPR1
Entrez 3708
HUGO 6180
OMIM 147265
RefSeq NM_002222
UniProt Q14643
Other data
Locus Chr. 3 p26.1
inositol 1,4,5-triphosphate receptor, type 2
Identifiers
Symbol ITPR2
Entrez 3709
HUGO 6181
OMIM 600144
RefSeq NM_002223
UniProt Q14571
Other data
Locus Chr. 12 p11.23
inositol 1,4,5-triphosphate receptor, type 3
Identifiers
Symbol ITPR3
Entrez 3710
HUGO 6182
OMIM 147267
RefSeq NM_002224
UniProt Q14573
Other data
Locus Chr. 6 p21.31

Inositol triphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca2+ channel activated by inositol triphosphate (IP3). The IP3 receptor was first purified from rat cerebellum[1].

Contents

Distribution

It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the IP3R's are found in the cell integrated into the endoplasmic reticulum.

Structure

The IP3R complex is formed of four 313 kDa subunits. In amphibians, fish and mammals there are 3 paralogs and these can form homo- or hetero-oligomers. IP3R-1 is the most widely expressed of these three and is found in all tissue types and all developmental stages of life. It is additionally the means for further IP3 receptor diversity in that it has as many as four splice sites with as many as 9 different optional exons or exon variants. Combinations of these can be introduced into a given transcript in order to modulate its pharmacological activity.

See also

References

  1. ^ Inositol trisphosphate receptor Ca2+ release chann...[Physiol Rev. 2007] - PubMed Result

External links

 This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Cell signaling: lipid signaling
Phospholipase - PIP2 - DAG - IP3 - IP3 receptor
v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channel
Voltage-dependent calcium channel (L-type/Cavα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Cavα(2.1), Q-type, R-type, T-type, α2δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4)
Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Navβ (1, 2, 3, 4) • Epithelial sodium channel
K+: Potassium channel
Cl-: Chloride channel
Porin
Cations: TRP
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Other/general

Wikipedia content modification information:

  • This page was last modified on 15 June 2008, at 13:48.

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