Itpr1

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Inositol 1,4,5-triphosphate receptor, type 1
PDB rendering based on 1n4k.
Available structures: 1n4k, 1xzz
Identifiers
Symbols ITPR1; IP3R; IP3R1; Insp3r1
External IDs OMIM: 147265 MGI: 96623 HomoloGene: 1673
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3708 16438
Ensembl ENSG00000150995 ENSMUSG00000030102
Uniprot Q14643 Q3UVA1
Refseq NM_002222 (mRNA)
NP_002213 (protein)		 NM_010585 (mRNA)
NP_034715 (protein)
Location Chr 3: 4.51 - 4.86 Mb Chr 6: 108.18 - 108.52 Mb
Pubmed search [1] [2]

Inositol 1,4,5-triphosphate receptor, type 1, also known as ITPR1, is a human gene.1


Contents

See also

References

  1. ^ "Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1".

Further reading

  • Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects.". Curr. HIV Res. 4 (1): 57–64. PMID 16454711. 
  • Nucifora FC, Li SH, Danoff S, et al. (1996). "Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant.". Brain Res. Mol. Brain Res. 32 (2): 291–6. PMID 7500840. 
  • Joseph SK, Lin C, Pierson S, et al. (1995). "Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.". J. Biol. Chem. 270 (40): 23310–6. PMID 7559486. 
  • Harnick DJ, Jayaraman T, Ma Y, et al. (1995). "The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation.". J. Biol. Chem. 270 (6): 2833–40. PMID 7852357. 
  • Yamada N, Makino Y, Clark RA, et al. (1994). "Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization.". Biochem. J. 302 ( Pt 3): 781–90. PMID 7945203. 
  • Wojcikiewicz RJ, Furuichi T, Nakade S, et al. (1994). "Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation.". J. Biol. Chem. 269 (11): 7963–9. PMID 8132516. 
  • Komalavilas P, Lincoln TM (1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase.". J. Biol. Chem. 269 (12): 8701–7. PMID 8132598. 
  • Cameron AM, Steiner JP, Roskams AJ, et al. (1996). "Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux.". Cell 83 (3): 463–72. PMID 8521476. 
  • Yan J, Khanna KK, Lavin MF (1996). "Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation.". Int. J. Radiat. Biol. 69 (5): 539–46. PMID 8648241. 
  • Quinton TM, Dean WL (1996). "Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets.". Biochem. Biophys. Res. Commun. 224 (3): 740–6. doi:10.1006/bbrc.1996.1093. PMID 8713116. 
  • Cameron AM, Nucifora FC, Fung ET, et al. (1997). "FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain.". J. Biol. Chem. 272 (44): 27582–8. PMID 9346894. 
  • Deelman LE, Jonk LJ, Henning RH (1998). "The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor.". Gene 207 (2): 219–25. PMID 9511764. 
  • Martin C, Chapman KE, Seckl JR, Ashley RH (1998). "Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.". Neuroscience 85 (1): 205–16. PMID 9607712. 
  • Tu JC, Xiao B, Yuan JP, et al. (1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.". Neuron 21 (4): 717–26. PMID 9808459. 
  • Kiselyov K, Xu X, Mozhayeva G, et al. (1998). "Functional interaction between InsP3 receptors and store-operated Htrp3 channels.". Nature 396 (6710): 478–82. doi:10.1038/24890. PMID 9853757. 
  • Lin P, Yao Y, Hofmeister R, et al. (1999). "Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi.". J. Cell Biol. 145 (2): 279–89. PMID 10209024. 
  • Schlossmann J, Ammendola A, Ashman K, et al. (2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta.". Nature 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800. 
  • Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538–42. PMID 10843712. 
  • Tanimura A, Tojyo Y, Turner RJ (2000). "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.". J. Biol. Chem. 275 (35): 27488–93. doi:10.1074/jbc.M004495200. PMID 10874040. 

External links

 This article on a gene on chromosome 3 is a stub. You can help Wikipedia by expanding it.
v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channel
L-type/Cavα (1.1, 1.2, 1.3, 1.4) • N-type/Cavα2.2 • P-type/Cavα(2.1) • Q-type/Cavα2.1 • R-type/Cavα2.3 • T-type/Cavα(3.2)
α2δ-subunits (1, 2) • β-subunits (β1, β2, β3, β4) • γ-subunits (γ1, γ2, γ3, γ4)
Cation channels of sperm • Two-pore channel (1, 2)
Ligand-gated
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) • Navβ (1, 2, 3, 4)
Other
K+: Potassium channel
Kvα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10) • (2.1, 2.2) • (3.1, 3.2, 3.3, 3.4) • (4.1, 4.2, 4.3) • (5.1) • (6.1, 6.2, 6.3, 6.4)
Kvα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) • (8.1, 8.2) • (9.1, 9.2, 9.3) • (10.1, 10.2) • (11.1/hERG, 11.2, 11.3) • (12.1, 12.2, 12.3)
Kvβ (1, 2, 3) • KCNIP (1, 2, 3, 4) • minK/ISK • MiRP (1, 2, 3) • Shaker gene
Kir (1.1, 2.1, 2.2, 2.3, 2.4) • GIRK/Kir (3.1, 3.2, 3.3, 3.4) • Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)
M+: TRP cation channel
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (1, 2, 3) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Cl-: Chloride channel
ANO1 • Bestrophin (1, 2)  • CFTR • CLCA (1, 2, 3, 4) • CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) • CLIC (1, 2, 3, 4, 5, 6, L1) • CLNS (1A, 1B)
Cyclic nucleotide-gated
α (1, 2, 3, 4) • β (1, 2, 3) • HCN (1, 2, 3, 4)
Porin
Other/general

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  • This page was last modified on 13 July 2008, at 12:43.

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