JUND

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Jun D proto-oncogene

Available structures

PDB

Ortholog search: PDBe, RCSB

List of PDB id codes
3U86

Identifiers

Symbols

JUND; AP-1

External IDs

OMIM: 165162 MGI: 96648 HomoloGene: 3910 GeneCards: JUND Gene

Gene Ontology
Molecular function	• double-stranded DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • ligand-dependent nuclear receptor binding • sequence-specific DNA binding • transcription regulatory region DNA binding
Cellular component	• chromatin • nucleus • protein complex
Biological process	• osteoblast development • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • aging • circadian rhythm • response to light stimulus • response to mechanical stimulus • response to organic cyclic compound • response to lipopolysaccharide • response to peptide hormone stimulus • positive regulation of osteoblast differentiation • positive regulation of transcription from RNA polymerase II promoter • cellular response to calcium ion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
18.39 – 18.39 Mb

Chr 8:
70.7 – 70.7 Mb

PubMed search

[1]

[2]

Transcription factor jun-D is a protein that in humans is encoded by the JUND gene.^[1]^[2]

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms.^[3]

1 Interactions
2 See also
3 References
4 Further reading
5 External links

Interactions

JunD has been shown to interact with ATF3,^[4] MEN1,^[5] DNA damage-inducible transcript 3^[6] and BRCA1.^[7]

References

^ Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R (July 1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D". Nucleic Acids Res 18 (10): 3047–8. doi:10.1093/nar/18.10.3047. PMC 330838. PMID 2112242.
^ Berger I, Shaul Y (June 1991). "Structure and function of human jun-D". Oncogene 6 (4): 561–6. PMID 1903194.
^ "Entrez Gene: JUND jun D proto-oncogene".
^ Chu, H M; Tan Y, Kobierski L A, Balsam L B, Comb M J (January 1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression". Mol. Endocrinol. (UNITED STATES) 8 (1): 59–68. doi:10.1210/me.8.1.59. ISSN 0888-8809. PMID 8152431.
^ Agarwal, S K; Guru S C, Heppner C, Erdos M R, Collins R M, Park S Y, Saggar S, Chandrasekharappa S C, Collins F S, Spiegel A M, Marx S J, Burns A L (January 1999). "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell (UNITED STATES) 96 (1): 143–52. doi:10.1016/S0092-8674(00)80967-8. ISSN 0092-8674. PMID 9989505.
^ Ubeda, M; Vallejo M, Habener J F (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589–99. ISSN 0270-7306. PMC 84780. PMID 10523647.
^ Hu, Yan-Fen; Li Rong (June 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. (United States) 16 (12): 1509–17. doi:10.1101/gad.995502. ISSN 0890-9369. PMC 186344. PMID 12080089.

Mollinedo F, Vaquerizo MJ, Naranjo JR (1991). "Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.". Biochem. J. 273(Pt 2): 477–9. PMC 1149869. PMID 1899335.
Franklin CC, McCulloch AV, Kraft AS (1995). "In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.". Biochem. J. 305 (3): 967–74. PMC 1136352. PMID 7848298.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Chu HM, Tan Y, Kobierski LA, et al. (1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression.". Mol. Endocrinol. 8 (1): 59–68. doi:10.1210/me.8.1.59. PMID 8152431.
Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
Dorsey MJ, Tae HJ, Sollenberger KG, et al. (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.". Oncogene 11 (11): 2255–65. PMID 8570175.
Claret FX, Hibi M, Dhut S, et al. (1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.". Nature 383 (6599): 453–7. doi:10.1038/383453a0. PMID 8837781.
Kallunki T, Deng T, Hibi M, Karin M (1997). "c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.". Cell 87 (5): 929–39. doi:10.1016/S0092-8674(00)81999-6. PMID 8945519.
Aronheim A, Zandi E, Hennemann H, et al. (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.". Mol. Cell. Biol. 17 (6): 3094–102. PMC 232162. PMID 9154808.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Labudova O, Krapfenbauer K, Moenkemann H, et al. (1998). "Decreased transcription factor junD in brains of patients with Down syndrome.". Neurosci. Lett. 252 (3): 159–62. doi:10.1016/S0304-3940(98)00569-2. PMID 9739985.
Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.". Oncogene 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. PMID 9872330.
Agarwal SK, Guru SC, Heppner C, et al. (1999). "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.". Cell 96 (1): 143–52. doi:10.1016/S0092-8674(00)80967-8. PMID 9989505.
Liberati NT, Datto MB, Frederick JP, et al. (1999). "Smads bind directly to the Jun family of AP-1 transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. doi:10.1073/pnas.96.9.4844. PMC 21779. PMID 10220381.
Gobl AE, Berg M, Lopez-Egido JR, et al. (1999). "Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism.". Biochim. Biophys. Acta 1447 (1): 51–6. doi:10.1016/S0167-4781(99)00132-3. PMID 10500243.
Ubeda M, Vallejo M, Habener JF (1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.". Mol. Cell. Biol. 19 (11): 7589–99. PMC 84780. PMID 10523647.
Miyamoto NG, Medberry PS, Hesselgesser J, et al. (2000). "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors.". J. Neuroimmunol. 105 (1): 78–90. doi:10.1016/S0165-5728(00)00195-8. PMID 10713367.
Sharma SC, Richards JS (2000). "Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation.". J. Biol. Chem. 275 (43): 33718–28. doi:10.1074/jbc.M003555200. PMID 10934195.

External links

JUND protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
FactorBook JunD

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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JUND

Contents

Interactions

See also

References

Further reading

External links