KCNIP3

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Kv channel interacting protein 3, calsenilin
Identifiers
Symbols KCNIP3; CSEN; DREAM; KCHIP3; MGC18289
External IDs OMIM: 604662 MGI: 1929258 HomoloGene: 8382
Orthologs
Human Mouse
Entrez 30818 56461
Ensembl ENSG00000115041 n/a
Uniprot Q9Y2W7 n/a
Refseq NM_001034914 (mRNA)
NP_001030086 (protein)		 NM_019789 (mRNA)
NP_062763 (protein)
Location Chr 2: 95.33 - 95.42 Mb n/a
Pubmed search [1] [2]

Kv channel interacting protein 3, calsenilin, also known as KCNIP3, is a human gene.[1]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.[1]

Contents

See also

References

  1. ^ a b "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin".

Further reading

  • Buxbaum JD, Choi EK, Luo Y, et al. (1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment.". Nat. Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752. 
  • Carrión AM, Mellström B, Naranjo JR (1998). "Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element.". Mol. Cell. Biol. 18 (12): 6921–9. PMID 9819380. 
  • Carrión AM, Link WA, Ledo F, et al. (1999). "DREAM is a Ca2+-regulated transcriptional repressor.". Nature 398 (6722): 80–4. doi:10.1038/18044. PMID 10078534. 
  • An WF, Bowlby MR, Betty M, et al. (2000). "Modulation of A-type potassium channels by a family of calcium sensors.". Nature 403 (6769): 553–6. doi:10.1038/35000592. PMID 10676964. 
  • Leissring MA, Yamasaki TR, Wasco W, et al. (2000). "Calsenilin reverses presenilin-mediated enhancement of calcium signaling.". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8590–3. PMID 10900016. 
  • Buxbaum JD, Lilliehook C, Chan JY, et al. (2000). "Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease.". Neurosci. Lett. 294 (3): 135–8. PMID 11072133. 
  • Ledo F, Carrión AM, Link WA, et al. (2001). "DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription.". Mol. Cell. Biol. 20 (24): 9120–6. PMID 11094064. 
  • Jo DG, Kim MJ, Choi YH, et al. (2001). "Pro-apoptotic function of calsenilin/DREAM/KChIP3.". FASEB J. 15 (3): 589–91. doi:10.1096/fj.00-0541fje. PMID 11259376. 
  • Choi EK, Zaidi NF, Miller JS, et al. (2001). "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2.". J. Biol. Chem. 276 (22): 19197–204. doi:10.1074/jbc.M008597200. PMID 11278424. 
  • Osawa M, Tong KI, Lilliehook C, et al. (2001). "Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3.". J. Biol. Chem. 276 (44): 41005–13. doi:10.1074/jbc.M105842200. PMID 11535596. 
  • Cheng HY, Pitcher GM, Laviolette SR, et al. (2002). "DREAM is a critical transcriptional repressor for pain modulation.". Cell 108 (1): 31–43. PMID 11792319. 
  • Lilliehook C, Chan S, Choi EK, et al. (2002). "Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling.". Mol. Cell. Neurosci. 19 (4): 552–9. doi:10.1006/mcne.2001.1096. PMID 11988022. 
  • Takimoto K, Yang EK, Conforti L (2002). "Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels.". J. Biol. Chem. 277 (30): 26904–11. doi:10.1074/jbc.M203651200. PMID 12006572. 
  • Ledo F, Kremer L, Mellström B, Naranjo JR (2002). "Ca2+-dependent block of CREB-CBP transcription by repressor DREAM.". EMBO J. 21 (17): 4583–92. PMID 12198160. 
  • Zaidi NF, Berezovska O, Choi EK, et al. (2002). "Biochemical and immunocytochemical characterization of calsenilin in mouse brain.". Neuroscience 114 (1): 247–63. PMID 12207970. 
  • Sanz C, Horita M, Fernandez-Luna JL (2004). "Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells.". Haematologica 87 (9): 903–7. PMID 12217801. 
  • Schrader LA, Anderson AE, Mayne A, et al. (2002). "PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex.". J. Neurosci. 22 (23): 10123–33. PMID 12451113. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hong YM, Jo DG, Lee MC, et al. (2003). "Reduced expression of calsenilin/DREAM/KChIP3 in the brains of kainic acid-induced seizure and epilepsy patients.". Neurosci. Lett. 340 (1): 33–6. PMID 12648752. 
  • Shibata R, Misonou H, Campomanes CR, et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.". J. Biol. Chem. 278 (38): 36445–54. doi:10.1074/jbc.M306142200. PMID 12829703. 

External links

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v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channel
L-type/Cavα (1.1, 1.2, 1.3, 1.4) • N-type/Cavα2.2 • P-type/Cavα(2.1) • Q-type/Cavα2.1 • R-type/Cavα2.3 • T-type/Cavα(3.2)
α2δ-subunits (1, 2) • β-subunits (β1, β2, β3, β4) • γ-subunits (γ1, γ2, γ3, γ4)
Cation channels of sperm • Two-pore channel (1, 2)
Ligand-gated
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) • Navβ (1, 2, 3, 4)
Other
K+: Potassium channel
Kvα (1-6) (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10, 2.1, 2.2, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 4.3, 5.1, 6.1, 6.2, 6.3, 6.4)
Kvα (7-12) (7.1, 7.2, 7.3, 7.4, 7.5, 8.1, 8.2, 9.1, 9.2, 9.3, 10.1, 10.2, 11.1/hERG, 11.2, 11.3, 12.1, 12.2, 12.3)
Kvβ (1, 2, 3) • KCNIP (1, 2, 3, 4) • minK/ISK • MiRP (1, 2, 3) • Shaker gene
Kir (1.1, 2.1, 2.2, 2.3, 2.4) • GIRK/Kir (3.1, 3.2, 3.3, 3.4) • Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)
M+: TRP cation channel
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (1, 2, 3) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Cl-: Chloride channel
CFTR • CLCA (1, 2, 3, 4) • CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) • CLIC (1, 2, 3, 4, 5, 6, L1) • CLNS (1A, 1B)
Cyclic nucleotide-gated
α1, α2, α3, α4, β1, β3, H1, H2, H3, H4
Porin
Other/general


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