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Kallikrein-related peptidase 6, also known as KLK6, is a human gene.[1]
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.[1]
References
Further reading
- Yousef GM, Kishi T, Diamandis EP (2003). "Role of kallikrein enzymes in the central nervous system.". Clin. Chim. Acta 329 (1-2): 1–8. PMID 12589961.
- Anisowicz A, Sotiropoulou G, Stenman G, et al. (1997). "A novel protease homolog differentially expressed in breast and ovarian cancer.". Mol. Med. 2 (5): 624–36. PMID 8898378.
- Yamashiro K, Tsuruoka N, Kodama S, et al. (1997). "Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain.". Biochim. Biophys. Acta 1350 (1): 11–4. PMID 9003450.
- Little SP, Dixon EP, Norris F, et al. (1997). "Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain.". J. Biol. Chem. 272 (40): 25135–42. PMID 9312124.
- Yousef GM, Luo LY, Scherer SW, et al. (2000). "Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease.". Genomics 62 (2): 251–9. doi:. PMID 10610719.
- Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.". Gene 257 (1): 119–30. PMID 11054574.
- Petraki CD, Karavana VN, Skoufogiannis PT, et al. (2001). "The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry.". J. Histochem. Cytochem. 49 (11): 1431–41. PMID 11668196.
- Bernett MJ, Blaber SI, Scarisbrick IA, et al. (2002). "Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system.". J. Biol. Chem. 277 (27): 24562–70. doi:. PMID 11983703.
- Gomis-Rüth FX, Bayés A, Sotiropoulou G, et al. (2002). "The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family.". J. Biol. Chem. 277 (30): 27273–81. doi:. PMID 12016211.
- Scarisbrick IA, Blaber SI, Lucchinetti CF, et al. (2002). "Activity of a newly identified serine protease in CNS demyelination.". Brain 125 (Pt 6): 1283–96. PMID 12023317.
- Zarghooni M, Soosaipillai A, Grass L, et al. (2002). "Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients.". Clin. Biochem. 35 (3): 225–31. PMID 12074831.
- Hoffman BR, Katsaros D, Scorilas A, et al. (2002). "Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker.". Br. J. Cancer 87 (7): 763–71. doi:. PMID 12232761.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Mitsui S, Okui A, Uemura H, et al. (2003). "Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease.". Ann. N. Y. Acad. Sci. 977: 216–23. PMID 12480753.
- Hutchinson S, Luo LY, Yousef GM, et al. (2003). "Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin.". Clin. Chem. 49 (5): 746–51. PMID 12709365.
- Magklara A, Mellati AA, Wasney GA, et al. (2003). "Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors.". Biochem. Biophys. Res. Commun. 307 (4): 948–55. PMID 12878203.
- Iwata A, Maruyama M, Akagi T, et al. (2004). "Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies.". Hum. Mol. Genet. 12 (20): 2625–35. doi:. PMID 12928483.
- Sauter ER, Lininger J, Magklara A, et al. (2004). "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk.". Int. J. Cancer 108 (4): 588–91. doi:. PMID 14696124.
- Pampalakis G, Kurlender L, Diamandis EP, Sotiropoulou G (2004). "Cloning and characterization of novel isoforms of the human kallikrein 6 gene.". Biochem. Biophys. Res. Commun. 320 (1): 54–61. doi:. PMID 15207701.
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