Latanoprost

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Latanoprost
Systematic (IUPAC) name
isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2- [(3R)3-hydroxy-5-phenylpentyl]-cyclopentyl] hept-5-enoate
Identifiers
CAS number 130209-82-4
ATC code S01EE01
PubChem 60798
DrugBank APRD01065
Chemical data
Formula C26H40O5 
Mol. mass 432.593 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 17 minutes
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Topical (eye drops)

Latanoprost (pronounced la-TA-noe-prost) ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes.

It is also known by the brand name of Xalatan manufactured by Pfizer.

Side effects

Possible side effects:

  • May cause reddening of the eyes (hyperemia)
  • May cause blurred vision;
  • May cause eyelid redness;
  • May permanently darken eyelashes;
  • May cause eye discomfort;
  • May eventually cause permanent darkening of the iris to brown (heterochromia);
  • May cause a temporary burning sensation during use.
  • May cause thickening of the eyelashes.
  • Rarely, herpes simplex keratitis.

External links

  • Xalatan (manufacturer's website)
  • Hara T (2001). "Increased iris pigmentation after use of latanoprost in Japanese brown eyes". Nippon Ganka Gakkai Zasshi 105 (5): 314–21. PMID 11406947. 



Wikipedia content modification information:

  • This page was last modified on 27 May 2008, at 16:44.

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