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| Image:Lepirudin.png | |
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Lepirudin
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| Systematic (IUPAC) name | |
| ? | |
| Identifiers | |
| CAS number | |
| ATC code | B01 |
| PubChem | ? |
| DrugBank | |
| Chemical data | |
| Formula | C288H448N80O110S6 |
| Mol. mass | 6983.5 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 100% |
| Metabolism | ? |
| Half life | ~1.3 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
B(US) |
| Legal status | |
| Routes | SQ or IV |
Lepirudin (Refludan ) is an anticoagulant which functions as a direct thrombin inhibitor.
It is derived from the saliva of the medicinal leech Hirudo medicinalis.
Lepirudin may be used as a medication in Heparin-induced thrombocytopenia.
External links
- Hirudo Medicinalis TURKEY, Supplier of Hirudo Medicinalis
- http://www.tibbisuluk.com Hirudo Medicinalis TURKEY,
- DDB 30082
- Smythe M, Stephens J, Koerber J, Mattson J (2005). "A comparison of lepirudin and argatroban outcomes.". Clin Appl Thromb Hemost 11 (4): 371–4. doi:. PMID 16244762.
- "Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudin." . Blood. PMID 16690967.
- Lubenow N, Eichler P, Lietz T, Greinacher A (2005). "Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3.". J Thromb Haemost 3 (11): 2428–36. doi:. PMID 16241940.
- http://www.refludan.com/product/index.htm
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Wikipedia content modification information:
- This page was last modified on 31 May 2008, at 14:24.
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