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Annexin A1 (or Lipocortin I) is a human protein encoded by the ANXA1 gene. Annexin I belongs to a family of Ca(2+)-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins, and leukotrienes, annexin I may have potential anti-inflammatory activity.[1] The gene for annexin A1 (ANXA1) is upregulated in hairy cell leukemia.
ANXA1 protein expression is specific to hairy cell leukemia.
Detection of ANXA1 (by immunocytochemical means) reportedly provides a simple, highly-sensitive and specific assay for the diagnosis of hairy cell leukemia.
Glucocorticoid stimulate production of lipocortin.
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See also
References
Further reading
- Crompton MR, Moss SE, Crumpton MJ (1988). "Diversity in the lipocortin/calpactin family.". Cell 55 (1): 1–3. PMID 2971450.
- Lim LH, Pervaiz S (2007). "Annexin 1: the new face of an old molecule.". FASEB J. 21 (4): 968–75. doi:. PMID 17215481.
- Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151.
- Ando Y, Imamura S, Owada MK, Kannagi R (1991). "Calcium-induced intracellular cross-linking of lipocortin I by tissue transglutaminase in A431 cells. Augmentation by membrane phospholipids.". J. Biol. Chem. 266 (2): 1101–8. PMID 1670773.
- Kovacic RT, Tizard R, Cate RL, et al. (1991). "Correlation of gene and protein structure of rat and human lipocortin I.". Biochemistry 30 (37): 9015–21. PMID 1832554.
- Varticovski L, Chahwala SB, Whitman M, et al. (1988). "Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.". Biochemistry 27 (10): 3682–90. PMID 2457390.
- Pepinsky RB, Sinclair LK, Chow EP, O'Brine-Greco B (1990). "A dimeric form of lipocortin-1 in human placenta.". Biochem. J. 263 (1): 97–103. PMID 2532504.
- Wallner BP, Mattaliano RJ, Hession C, et al. (1986). "Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity.". Nature 320 (6057): 77–81. doi:. PMID 2936963.
- Kaplan R, Jaye M, Burgess WH, et al. (1988). "Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein.". J. Biol. Chem. 263 (17): 8037–43. PMID 2967291.
- Huebner K, Cannizzaro LA, Frey AZ, et al. (1988). "Chromosomal localization of the human genes for lipocortin I and lipocortin II.". Oncogene Res. 2 (4): 299–310. PMID 2969496.
- Biemann K, Scoble HA (1987). "Characterization by tandem mass spectrometry of structural modifications in proteins.". Science 237 (4818): 992–8. PMID 3303336.
- Arcone R, Arpaia G, Ruoppolo M, et al. (1993). "Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli.". Eur. J. Biochem. 211 (1-2): 347–55. PMID 8425544.
- Weng X, Luecke H, Song IS, et al. (1993). "Crystal structure of human annexin I at 2.5 A resolution.". Protein Sci. 2 (3): 448–58. PMID 8453382.
- Mailliard WS, Haigler HT, Schlaepfer DD (1996). "Calcium-dependent binding of S100C to the N-terminal domain of annexin I.". J. Biol. Chem. 271 (2): 719–25. PMID 8557678.
- Morgan RO, Fernández MP (1996). "A BC200-derived element and Z-DNA as structural markers in annexin I genes: relevance to Alu evolution and annexin tetrad formation.". J. Mol. Evol. 41 (6): 979–85. PMID 8587144.
- Almawi WY, Saouda MS, Stevens AC, et al. (1997). "Partial mediation of glucocorticoid antiproliferative effects by lipocortins.". J. Immunol. 157 (12): 5231–9. PMID 8955167.
- Croxtall JD, Wu HL, Yang HY, et al. (1998). "Lipocortin 1 co-associates with cytokeratins 8 and 18 in A549 cells via the N-terminal domain.". Biochim. Biophys. Acta 1401 (1): 39–51. PMID 9459484.
- Gao J, Li Y, Yan H (1999). "NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit.". J. Biol. Chem. 274 (5): 2971–7. PMID 9915835.
- Manda R, Kohno T, Matsuno Y, et al. (1999). "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display.". Genomics 61 (1): 5–14. doi:. PMID 10512675.
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