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| Lipstatin | |
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| IUPAC name | [(2S,4E,7E)-1-(3-hexyl-4-oxo-oxetan-2-yl) trideca-4,7-dien-2-yl](2S)-2-formamido- 3-methyl-pentanoate |
| Identifiers | |
| CAS number | [96829-59-3] |
| PubChem | |
| MeSH | |
| SMILES |
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| Properties | |
| Molecular formula | C29H49NO5 |
| Molar mass | 491.703 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Lipstatin is a potent, irreversible inhibitor of pancreatic lipase. It is a natural product, and was first isolated from the Actinobacterium Streptomyces toxytricini.[1]
The popular antiobesity drug orlistat (trade names Xenical and alli) is a saturated derivative of lipstatin.
References
- ^ Weibel E, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H (1987). "Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity". J Antibiot (Tokyo) 40 (8): 1081–5. PMID 3680018.
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