MASP1 (protein)

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mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Identifiers
Symbol MASP1
Alt. Symbols CRARF, PRSS5
Entrez 5648
HUGO 6901
OMIM 600521
RefSeq NM_001879
UniProt P48740
Other data
Locus Chr. 3 q27-q28

Mannose-associated serine protease 1 (MASP1) is a human gene.[1][2]

The protein encoded by this gene is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 to form C4b2a, a C3-convertase.[3]

See also

References

  1. ^ Takada F, Takayama Y, Hatsuse H, Kawakami M (October 1993). "A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum". Biochem. Biophys. Res. Commun. 196 (2): 1003–9. doi:10.1006/bbrc.1993.2349. PMID 8240317. 
  2. ^ Sato T, Endo Y, Matsushita M, Fujita T (April 1994). "Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein". Int. Immunol. 6 (4): 665–9. PMID 8018603. 
  3. ^ Matsushita M, Thiel S, Jensenius JC, Terai I, Fujita T (September 2000). "Proteolytic activities of two types of mannose-binding lectin-associated serine protease". J. Immunol. 165 (5): 2637–42. PMID 10946292. 

External links

 This article on a gene on chromosome 3 is a stub. You can help Wikipedia by expanding it.
v • d • e
Proteins: complement system (C, L, A)
Activators/enzymes
Early
C: C1Q/C1R/C1S - C4 (C4a) - C2
L: MASP1/MASP2 - MBL
Middle
Late
CLA: MAC (C6, C7, C8, C9)
Inhibitors
Complement receptors
v • d • e
Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes
Coagulation
Complement system
Other immune system
Venombin
Other

Wikipedia content modification information:

  • This page was last modified on 1 September 2008, at 19:16.

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