MYH1

This MedLibrary.org supplementary page on MYH1 is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

Myosin, heavy chain 1, skeletal muscle, adult
PDB rendering based on 1m8q.
Available structures: 1m8q, 1mvw, 1o18, 1o19, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o1g
Identifiers
Symbols MYH1; MGC133384; MYHSA1; MYHa; MyHC-2X/D
External IDs OMIM: 160730 MGI: 1339711 HomoloGene: 68493
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4619 17879
Ensembl ENSG00000109061 ENSMUSG00000056328
Uniprot P12882 Q9WUS6
Refseq NM_005963 (mRNA)
NP_005954 (protein)		 NM_030679 (mRNA)
NP_109604 (protein)
Location Chr 17: 10.34 - 10.36 Mb Chr 11: 67.02 - 67.04 Mb
Pubmed search [1] [2]

Myosin, heavy chain 1, skeletal muscle, adult, also known as MYH1, is a human gene.[1]

Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development.[1]

References

  1. ^ a b "Entrez Gene: MYH1 myosin, heavy chain 1, skeletal muscle, adult".

Further reading

  • Yoon SJ, Seiler SH, Kucherlapati R, Leinwand L (1993). "Organization of the human skeletal myosin heavy chain gene cluster.". Proc. Natl. Acad. Sci. U.S.A. 89 (24): 12078–82. PMID 1465443. 
  • Saez L, Leinwand LA (1986). "Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle.". Nucleic Acids Res. 14 (7): 2951–69. PMID 2421254. 
  • Leinwand LA, Saez L, McNally E, Nadal-Ginard B (1983). "Isolation and characterization of human myosin heavy chain genes.". Proc. Natl. Acad. Sci. U.S.A. 80 (12): 3716–20. PMID 6304733. 
  • Smerdu V, Karsch-Mizrachi I, Campione M, et al. (1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle.". Am. J. Physiol. 267 (6 Pt 1): C1723–8. PMID 7545970. 
  • Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. PMID 10077619. 
  • Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558. 
  • Daugaard JR, Nielsen JN, Kristiansen S, et al. (2000). "Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training.". Diabetes 49 (7): 1092–5. PMID 10909963. 
  • Korfage JA, Brugman P, Van Eijden TM (2000). "Intermuscular and intramuscular differences in myosin heavy chain composition of the human masticatory muscles.". J. Neurol. Sci. 178 (2): 95–106. PMID 11018701. 
  • Konig S, Burkman J, Fitzgerald J, et al. (2002). "Modular organization of phylogenetically conserved domains controlling developmental regulation of the human skeletal myosin heavy chain gene family.". J. Biol. Chem. 277 (31): 27593–605. doi:10.1074/jbc.M203162200. PMID 11971910. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMID 15121898. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Pontén EM, Stål PS (2007). "Decreased capillarization and a shift to fast myosin heavy chain IIx in the biceps brachii muscle from young adults with spastic paresis.". J. Neurol. Sci. 253 (1-2): 25–33. doi:10.1016/j.jns.2006.11.006. PMID 17196619. 
 This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

  • This page was last modified on 10 July 2008, at 02:10.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "MYH1".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.