MYH14

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Myosin, heavy chain 14
Identifiers
Symbols MYH14; DFNA4; DKFZp667A1311; FLJ13881; FLJ43092; FP17425; KIAA2034; NMHC-II-C
External IDs OMIM: 608568 MGI: 1919210 HomoloGene: 23480
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 79784 71960
Ensembl ENSG00000105357 n/a
Uniprot Q7Z406 n/a
Refseq NM_001077186 (mRNA)
NP_001070654 (protein)		 NM_028021 (mRNA)
NP_082297 (protein)
Location Chr 19: 55.4 - 55.51 Mb n/a
Pubmed search [1] [2]

Myosin, heavy chain 14, also known as MYH14, is a human gene.[1]

This gene encodes a member of the myosin superfamily. Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

References

  1. ^ a b "Entrez Gene: MYH14 myosin, heavy chain 14".

Further reading

  • Chen AH, Ni L, Fukushima K, et al. (1995). "Linkage of a gene for dominant non-syndromic deafness to chromosome 19.". Hum. Mol. Genet. 4 (6): 1073–6. PMID 7655461. 
  • Shoeman RL, Sachse C, Höner B, et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin.". Am. J. Pathol. 142 (1): 221–30. PMID 8424456. 
  • Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMID 11752456. 
  • Desjardins PR, Burkman JM, Shrager JB, et al. (2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family.". Mol. Biol. Evol. 19 (4): 375–93. PMID 11919279. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Leal A, Endele S, Stengel C, et al. (2003). "A novel myosin heavy chain gene in human chromosome 19q13.3.". Gene 312: 165–71. PMID 12909352. 
  • Golomb E, Ma X, Jana SS, et al. (2004). "Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family.". J. Biol. Chem. 279 (4): 2800–8. doi:10.1074/jbc.M309981200. PMID 14594953. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
  • Donaudy F, Snoeckx R, Pfister M, et al. (2004). "Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4).". Am. J. Hum. Genet. 74 (4): 770–6. doi:10.1086/383285. PMID 15015131. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMID 15498874. 
  • Kim KY, Kovács M, Kawamoto S, et al. (2005). "Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C.". J. Biol. Chem. 280 (24): 22769–75. doi:10.1074/jbc.M503488200. PMID 15845534. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
 This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.

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