Mebeverine

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Mebeverine
Systematic (IUPAC) name
 ?
Identifiers
CAS number  ?
ATC code A03AA04
PubChem  ?
Chemical data
Formula C25H36NO5 
Mol. mass 430.5595 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Mebeverine HCI is a musculotropic antispasmodic drug without atropic side-effects whose major therapeutic role is in the treatment of irritable bowel syndrome. It is also indicated for treatment of gastrointestinal spasm secondary to organic disorder. It was first registered in 1965 and manufacture by Solvay Pharmaceuticals.

Mebeverine HCI presented in tablets (100mg or 135mg), capsules (200mg slow release), and liquid (10mg/ml).

Mebeverine(Colofac) 135mg, Bought U.K.
Mebeverine(Colofac) 135mg, Bought U.K.

Mode of Action

Mebeverine is an antimuscarinic. Mebeverine HCI belongs to a group of compounds called musculotropic antispasmodics. These compounds act directly on the gut muscles at the cellular level to relax them. Mebeverine is also an inhibitor of calcium-depot replenishment. Therefore, mebeverine has dual mode of action which normalizes the small bowel motility.

Adverse effects

In a study [1] , most reactions consisted of urticaria or maculopapular rash, sometimes accompanied by fever, polyarthritis, thrombopenia or angioedema.

References

  1. ^ in 't Veld BA, van Puyenbroek E, Stricker BH. (1997). Hypersensitivity reactions to use of mebeverine, 1392-5.  Ned Tijdschr Geneeskd. 1997 Jul 12;141(28):1392-5. Hypersensitivity reactions to use of mebeverine [1] pubmed: 9380201
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Drugs for functional gastrointestinal disorders (A03)
Drugs for functional bowel disorders
Belladonna and derivatives
(antimuscarinics)
Propulsives

Wikipedia content modification information:

  • This page was last modified on 19 April 2008, at 11:00.

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