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Meclizine
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| Systematic (IUPAC) name | |
| 1-[(4-chlorophenyl)- phenyl-methyl]-4- [(3-methylphenyl)methyl]piperazine | |
| Identifiers | |
| CAS number | |
| ATC code | A04 R06 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C25H27ClN2 |
| Mol. mass | 390.948 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 6 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
B(US) |
| Legal status | |
| Routes | Oral |
Meclizine (proposed INN is meclozine) is an antihistamine considered to be an antiemetic. It is sold under the brand names of Bonine, Antivert and Postafen and is most commonly used to inhibit nausea and vomiting. An alternative to dimenhydrinate (Dramamine), meclizine is considered to be equally effective, but with reduced side effects.
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Uses
Motion sickness
Meclizine is effective in inhibiting the symptoms of motion sickness, such as nausea, vomiting, and dizziness.
Vertigo
Meclizine may be effective in relieving vertigo experienced as a result of inner ear infections or other conditions.
Risks of use
Drowsiness
Drowsiness may result as a side effect of taking meclizine. While the effects are less than those of dimenhydrinate, users are advised not to operate heavy machinery while under the influence. The consumption of alcohol while under the influence of meclizine may result in additional drowsiness.
Anticholinergics
Due to its possible anticholinergic action, meclizine should be used carefully with patients who suffer from asthma, glaucoma, or an enlarged prostate gland.
External links
- University of Berlin's Institute of Biochemistry
- Numark Pharmacies Information Page on Meclizine
- Rxlist Medical Dictionary
Wikipedia content modification information:
- This page was last modified on 7 October 2008, at 18:25.
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