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CD46 molecule, complement regulatory protein
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| PDB rendering based on 1ckl. | ||||||||||||||
| Available structures: 1ckl, 2o39 | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbols | CD46; MCP; MGC26544; MIC10; TLX; TRA2.10 | |||||||||||||
| External IDs | OMIM: 120920 MGI: 1203290 HomoloGene: 7832 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 4179 | 17221 | ||||||||||||
| Ensembl | ENSG00000117335 | ENSMUSG00000016493 | ||||||||||||
| Uniprot | P15529 | O88174 | ||||||||||||
| Refseq | NM_002389 (mRNA) NP_002380 (protein) |
NM_010778 (mRNA) NP_034908 (protein) |
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| Location | Chr 1: 205.99 - 206.04 Mb | Chr 1: 196.76 - 196.79 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
CD46 is an inhibitory complement receptor. The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.[1]
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- This page was last modified on 8 July 2008, at 04:26.
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