Mephobarbital

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Methylphenobarbital
Systematic (IUPAC) name
5-phenyl-5-ethyl-
3-methylbarbituric acid
Identifiers
CAS number 115-38-8
ATC code N03AA01
PubChem 8271
DrugBank APRD00047
Chemical data
Formula C13H14N2O3 
Mol. mass 246.3
Pharmacokinetic data
Bioavailability  ?
Protein binding 70-76%
Metabolism Hepatic
Half life 34 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status

Schedule IV(US)
Routes  ?

Methylphenobarbital, also known as mephobarbital, (marketed in the US under the brand name Mebaral by Ovation) is a drug which is a barbiturate derivative.

Methylphenobarbital is used as a sedative, anxiolytic and anticonvulsant. It is the N-methylated analogue of phenobarbital, and has similar indications, therapeutic value, and tolerability.

Approval History

  • 1935 Mebaral was introduced by Winthrop Pharmaceuticals.
  • 2001 Methylphenobarbital discontinued in the UK.
  • 2003 Mebaral acquired by Ovation Pharmaceuticals (specialty pharmaceutical company who acquire underpromoted branded pharmaceutical products).

Overdose symptoms

Symptoms of overdose of metharbital include confusion, decrease in or loss of reflexes, somnolence, pyrexia, irritability, hypothermia, poor judgment, shortness of breath or slow/troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness

References

  • The Treatment of Epilepsy 2nd Ed by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. ISBN 0-632-06046-8
v • d • e
Barbiturates (N01AF, N03AA, N05CA)

Allobarbital • Alphenal • Amobarbital • Aprobarbital • Barbexaclone • Barbital • Brallobarbital • Brophebarbital • Bucolome • Butabarbital • Butalbital • Butobarbital • Butallylonal • Crotylbarbital • Cyclobarbital • Cyclopal • Enallylpropymal • Ethallobarbital • Febarbamate • Heptabarbital • Hexethal • Hexobarbital • Mephobarbital • Metharbital • Methohexital • Methylphenobarbital • Narcobarbital • Nealbarbital • Pentobarbital • Phenobarbital • Phetharbital • Prazitone • Probarbital • Propallylonal • Proxibarbal • Proxibarbital • Reposal • Secbutabarbital • Secobarbital • Sigmodal • Spirobarbital • Talbutal • Thialbarbital • Thiamylal • Thiobarbital • Thiobutabarbital • Thiopental • Valofane • Vinbarbital • Vinylbital


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  • This page was last modified on 1 April 2008, at 15:02.

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