This MedLibrary.org supplementary page on Mesoridazine is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
 |
|
 |
|
|
Mesoridazine
|
|
| Systematic (IUPAC) name | |
| 10-{2-[(RS)1-Methylpiperidin-2-yl]ethyl}-2-methylsulfinyl-10H-phenothiazine | |
| Identifiers | |
| CAS number | |
| ATC code | N05 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C21H26N2OS2 |
| Mol. mass | 386.576 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 4% |
| Metabolism | Hepatic/Renal |
| Half life | 24 to 48 hours |
| Excretion | Biliary and renal |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status |
℞ Prescription only |
| Routes | oral, intravenous |
Mesoridazine besylate (sold as Serentil) is a piperidine antipsychotic neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia, organic brain disorders, psychoneuroses, and alcoholism. It is the besylate salt of a metabolite of thioridazine. Serious side effects include akathisia, tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome. It exerts its actions through blockade of central adrenergic receptors, dopamine receptors, serotonin receptors, and an anticholinergic blocking.[1] It also exerts part of its actions through depression of hypothalamic centers, like other phenothiazines.
Mesoridazine partially derives its name from the prefix "Meso"citation needed which means "middle" which is the center of the brain called the limbic system where most dopaminergic activity takes place. The middle of the brain also contains the pineal gland and hypothalamus.
For further information see: Phenothiazine
Mesoridazine was withdrawn from the United States market in 2004 due to causing irregular hearbeats.[1]
|
|||||||||||||||||||||||||||||||||||||||
References
- ^ "Facts and Comparisons" III W. Port Plaza, Suite 300 St. Louis MO. USA 63146-3098 (telephone 314-216-2100 or 1-800-223-0554). (Note this book is currently used by Rite Aid Pharmacies in the USA as a reference aid and it is a loose bound updatable book. The updatable section called "Antipsychotic Agents" is (c)1990
Wikipedia content modification information:
- This page was last modified on 28 May 2008, at 21:15.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Mesoridazine".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.