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Mitogen-activated protein kinase 8
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| PDB rendering based on 1jnk. | |||||||||||
| Available structures: 1jnk, 1pmn, 1pmq, 1pmu, 1pmv, 1ukh, 1uki, 2b1p, 2exc, 2g01, 2gmx, 2h96, 2no3, 2o0u, 2o2u, 2ok1 | |||||||||||
| Identifiers | |||||||||||
| Symbols | MAPK8; JNK; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1 | ||||||||||
| External IDs | OMIM: 601158 MGI: 1346861 HomoloGene: 56760 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 5599 | 26419 | |||||||||
| Ensembl | ENSG00000107643 | ENSMUSG00000021936 | |||||||||
| Uniprot | P45983 | Q544A0 | |||||||||
| Refseq | NM_002750 (mRNA) NP_002741 (protein) |
NM_016700 (mRNA) NP_057909 (protein) |
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| Location | Chr 10: 49.18 - 49.32 Mb | Chr 14: 32.21 - 32.28 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
Mitogen-activated protein kinase 8, also known as MAPK8, is a human gene.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]
References
Further reading
- Davis RJ (2000). "Signal transduction by the JNK group of MAP kinases.". Cell 103 (2): 239–52. PMID 11057897.
- Liu J, Lin A (2007). "Wiring the cell signaling circuitry by the NF-kappa B and JNK1 crosstalk and its applications in human diseases.". Oncogene 26 (22): 3267–78. doi:. PMID 17496921.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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- This page was last modified on 8 July 2008, at 06:14.
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