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Mitogen-activated protein kinase kinase (sic) is a kinase enzyme which phosphorylates mitogen-activated protein kinase. It is also known as MAP2K. It is classified as EC 2.7.12.2.
There are seven genes:
- MAP2K1 (aka MEK1)
- MAP2K2 (aka MEK2)
- MAP2K3 (aka MKK3)
- MAP2K4 (aka MKK4}
- MAP2K5 (aka MKK5)
- MAP2K6 (aka MKK6)
- MAP2K7 (aka MKK7)
The activators of p38 (MKK3 and MKK4), JNK (MKK4), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.[1]
References
- ^ Dérijard B, et al. (1995). "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms". Science 267 (5198): 682–5. doi:.
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- This page was last modified on 7 June 2008, at 15:08.
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