Mometasone furoate

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Mometasone furoate
Systematic (IUPAC) name
(9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16

-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
Identifiers
CAS number 105102-22-5 83919-23-7 as Furoate
ATC code D07AC13 D07XC03, R01AD09, R03BA07
PubChem 123620
DrugBank APRD00289
Chemical data
Formula C22H28Cl2O4 for Mometasone
C27H30O6Cl2 as Furoate
Mol. mass 427.361 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability Nasal spray is virtually undetectable in plasma
Protein binding 98% to 99%
Metabolism hepatic
Half life 5.8 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes topical, nasal

Mometasone furoate (also referred to as Mometasone) is a moderately potent glucocorticoid steroid used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), and asthma for patients unresponsive to less potent corticosteroids. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.

Schering-Plough markets the medication under the following brand names; Elocon (Elocom) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions.

Nasonex is known in the U.S. for a series of television ads featuring an animated bee which is voiced by the Spanish actor Antonio Banderas.

External links



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v • d • e
Corticosteroids - glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)
Mineralocorticoids
Glucocorticoids
Other/ungrouped
corticosteroids
Aldosterone antagonists
v • d • e
Decongestants and other nasal preparations (R01)
Topical
Antiallergic agents,
excluding corticosteroids
Other nasal preparations
Systemic use:
Sympathomimetics

Wikipedia content modification information:

  • This page was last modified on 28 May 2008, at 17:20.

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