This MedLibrary.org supplementary page on Monoamine transporter is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
Monoamine transporters are structures in nerve-cell membranes that function as neurotransmitter transporters transferring monoamine neurotransmitters in or out of cells.
Contents |
Types
There are several different monoamine transporters:
- The dopamine transporter, DAT.
- The norepinephrine transporter, NET.
- The serotonin transporter, SERT.
DAT, NET and SERT are relatedvague to each other, and each consists of a structure of 12 transmembrane helices.
Drug action
Many drugs, such as antidepressants and psychoactives affect the monoamine transporters.
Modern antidepressants typically work by enhancing serotonergic, noradrenergic or dopaminergic neurotransmission by binding to the corresponding transporter, and thereby inhibiting neurotransmitter reuptake and raising active levels in the synapse. Examples include fluoxetine, a selective serotonin reuptake inhibitor; reboxetine, a norepinephrine reuptake inhibitor and bupropion, which inhibits both the norepinephrine and dopamine transporter.
The euphoric and addictive properties of amphetamine, methamphetamine and cocaine are thought to come from their potent DAT-blocking activity.
See also
References
G.E. Torres, R.R. Gainetdinov and M.G. Caron (2003). "Plasma membrane monoamine transporters: structure, regulation and function". Nat. Rev. Neurosci. 4 (1): 13–25. doi:. PMID 12511858. (Review)
 |
This neuroscience article is a stub. You can help Wikipedia by expanding it. |
|
||||||||
Wikipedia content modification information:
- This page was last modified on 3 September 2008, at 07:41.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Monoamine transporter".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.