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In enzymology, a [myosin-light-chain] phosphatase (EC 3.1.3.53) is an enzyme that catalyzes the chemical reaction

[myosin light-chain] phosphate + H₂O [myosin light-chain] + phosphate

Thus, the two substrates of this enzyme are myosin light-chain phosphate and H₂O, whereas its two products are [[[myosin light-chain]]] and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [myosin-light-chain]-phosphate phosphohydrolase. Other names in common use include myosin light chain kinase phosphatase, myosin phosphatase, myosin phosphatase, protein phosphatase 2A, and myosin-light-chain-phosphatase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1S70.

References

• IUBMB entry for 3.1.3.53
• BRENDA references for 3.1.3.53 (Recommended.)
• PubMed references for 3.1.3.53
• PubMed Central references for 3.1.3.53
• Google Scholar references for 3.1.3.53
• Pato MD, Adelstein RS (1983). "Purification and characterization of a multisubunit phosphatase from turkey gizzard smooth muscle. The effect of calmodulin binding to myosin light chain kinase on dephosphorylation". J. Biol. Chem. 258: 7047–54. PMID 6304072. 

External links

The CAS registry number for this enzyme class is 86417-96-1.

• IUBMB entry for 3.1.3.53

• KEGG entry for 3.1.3.53

• BRENDA entry for 3.1.3.53

• NiceZyme view of 3.1.3.53

• EC2PDB: PDB structures for 3.1.3.53

• PRIAM entry for 3.1.3.53

• PUMA2 entry for 3.1.3.53

• IntEnz: Integrated Enzyme entry for 3.1.3.53

• MetaCyc entry for 3.1.3.53

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0050115: myosin-light-chain-phosphatase

• AMIGO entry for GO code 0050115: myosin-light-chain-phosphatase

This hydrolase article is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

• This page was last modified on 9 December 2007, at 20:23.

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